Effect of Enterococcus faecalis FK-23 on Anti-obesity in Diet-induced Obesity Mice

We examined the effect of heat treated Enterococcus faecalis FK-23 on anti-obesity. C57BL/6J mice (male, 5 weeks old) were fed control diet (Control group), high fat diet (High fat group) or high fat diet supplemented with 2% E. faecalis FK-23 mixture in water (FK-23 group) for 67 days. The effect of FK-23 on body weight, food intake, percent body fat, fat mass, epididymal fat pad weight, liver weight, lipids in liver, blood glucose, total cholesterol, adiponectin and leptin of these obese mice was examined. Body weight, fat mass, epididymal fat pad weight, blood glucose and leptin were significantly different between mice fed the high fat and FK-23 diets, while differences in food intake, percent body fat, liver weight, lipids in liver, total cholesterol and adiponectin were not significant. (Received Mar. 27, 2009; Accepted Jun. 22, 2009)