Joint modelling of multivariate longitudinal profiles: pitfalls of the random-effects approach

被引：89

作者：

Fieuws, S ^{[1
]}

Verbeke, G ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Ctr Biostat, B-3000 Louvain, Belgium

来源：

STATISTICS IN MEDICINE | 2004年 / 23卷 / 20期

关键词：

joint modelling; multivariate longitudinal profiles; mixed models;

D O I：

10.1002/sim.1885

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Due to its flexibility, the random-effects approach for the joint modelling of multivariate longitudinal profiles received a lot of attention in recent publications. In this approach different mixed models are joined by specifying a common distribution for their random-effects. Parameter estimates of this common distribution can then be used to evaluate the relation between the different responses. Using bivariate longitudinal measurements on pure-tone hearing thresholds, it will be shown that such a random-effects approach can yield misleading results for evaluating this relationship. Copyright (C) 2004 John Wiley Sons, Ltd.

引用

页码：3093 / 3104

页数：12

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