Education, occupation and retirement age effects on the age of onset of Alzheimer's disease

被引：27

作者：

Lupton, Michelle K. ^{[1
]}

Stahl, Daniel ^{[2
]}

Archer, Nicola ^{[3
]}

Foy, Catherine ^{[3
]}

Poppe, Michaela ^{[3
]}

Lovestone, Simon ^{[3
]}

Hollingworth, Paul ^{[4
]}

Williams, Julie ^{[4
]}

Owen, Micheal J. ^{[4
]}

Dowzell, Kimberley ^{[4
]}

Abraham, Richard ^{[4
]}

Sims, Rebecca ^{[4
]}

Brayne, Carol ^{[5
]}

Rubinsztein, David ^{[5
]}

Gill, Michael ^{[6
,7
]}

Lawlor, Brian ^{[6
,7
]}

Lynch, Aoibhinn ^{[6
,7
]}

Powell, John F. ^{[1
]}

机构：

[1] Kings Coll London, Dept Neurosci, Inst Psychiat, London, England

[2] Kings Coll London, Dept Biostat & Comp, Inst Psychiat, London, England

[3] Kings Coll London, Dept Old Age Psychiat, Inst Psychiat, London, England

[4] Cardiff Univ, Dept Psychol Med, Cardiff, Wales

[5] Univ Cambridge, Cambridge Inst Med Res, Cambridge CB2 1TN, England

[6] St James Hosp, Mercers Inst Res Aging, Dublin, Ireland

[7] Trinity Coll Dublin, Dublin, Ireland

来源：

INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY | 2010年 / 25卷 / 01期

基金：

英国惠康基金;

关键词：

Alzheimer's; cognitive research; occupation; retirement age; age of onset; MULTIPLE IMPUTATION; BLOOD-PRESSURE; LIFE-STYLE; DEMENTIA; RISK; INDIVIDUALS; ASSOCIATION; SYMPTOMS;

D O I：

10.1002/gps.2294

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Objective: To determine the effects of early life education, mid life employment and later life retirement age on the age of onset (AOO) of Alzheimer's disease (AD). Methods: Multiple regression analyses were carried out using data for 1320 probable AD cases, of which 382 were males with employment and retirement age data, using informant based information on education and employment. Results: No relation was found between years of education, best qualification obtained, or employment variables in males and the AOO of AD. A significant effect of later retirement age in delaying the AOO of AD was seen in males. Conclusions: In this study no effect of education or employment was seen, although this may be due to limited variance in the study population. The significant effect of retirement age may have several explanations, the most interesting of which would be the suggestion that active employment later in life allows an individual to prolong their cognitive assets above the threshold for dementia. Copyright (C) 2009 John Wiley & Sons, Ltd.

引用

页码：30 / 36

页数：7

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