Evidence of Bias in Studies of Influenza Vaccine Effectiveness in Elderly Patients

被引:49
作者
Baxter, Roger [1 ]
Lee, Janelle [2 ]
Fireman, Bruce [1 ]
机构
[1] Kaiser Permanente, Vaccine Study Ctr, Oakland, CA 94612 USA
[2] Kaiser Permanente, Div Res, Oakland, CA 94612 USA
关键词
MORTALITY; HOSPITALIZATIONS; PEOPLE; VIRUS;
D O I
10.1086/649568
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Although studies have shown influenza vaccines to be effective in preventing death in the elderly population, these findings may be the result of selection bias. We examined the relationship between vaccination, age, underlying morbidity, and probability of death in the upcoming year. Vaccination coverage varied in a curvilinear fashion with age, morbidity, and risk of death. Forgoing vaccination predicted death in those who had received vaccinations in the previous 5 years, but it predicted survival in patients who had never before received a vaccination. We conclude that bias is inherent in studies of influenza vaccination and death among elderly patients.
引用
收藏
页码:186 / 189
页数:4
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