Synthesis, antimicrobial and antiviral activity of substituted benzimidazoles

被引：62

作者：

Sharma, Deepika ^{[2
]}

Narasimhan, Balasubramanian ^{[1
]}

Kumar, Pradeep ^{[2
]}

Judge, Vikramjeet ^{[2
]}

Narang, Rakesh ^{[2
]}

De Clercq, Erik ^{[3
]}

Balzarini, Jan ^{[3
]}

机构：

[1] Maharshi Dayanand Univ, Fac Pharmaceut Sci, Rohtak 124001, Haryana, India

[2] Guru Jambheshwar Univ Sci & Technol, Dept Pharmaceut Sci, Hisar 125001, Haryana, India

[3] Katholieke Univ Leuven, Rega Inst Med Res, Lab Virol & Chemotherapy, B-3000 Louvain, Belgium

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2009年 / 24卷 / 05期

关键词：

Substituted benzimidazoles; antifungal activity; antiviral activity; ANTIFUNGAL ACTIVITY; QSAR; ANTIBACTERIAL; DERIVATIVES; VIRUS; DESIGN; ACID; INHIBITION;

D O I：

10.1080/14756360802694427

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the present study we have synthesized (4-nitrophenyl)-[2-(substituted phenyl)-benzoimidazol-1-yl]-methanones, (2-bromophenyl)-[2-(substituted phenyl)-benzoimiclazol-1-yl]-methanone analogues (1-14) and evaluated them for their antimicrobial and antiviral potential. The results of antimicrobial screening indicated that none of the synthesized compounds were effective against the tested bacterial strains. Compounds 3, 11, 13 and compounds 5, 11, 12 were found to be active against Aspergillus niger and Candida albicans respectively, and may be further developed as antifungal agents. Furthermore, evaluation against a panel of different viruses pointed out the selective activity of compounds 5 and 6 against vaccinia virus and Coxsackie virus B4.

引用

页码：1161 / 1168

页数：8

共 43 条

[1] Substituted benzimidazoles with nanomolar activity against respiratory syncytial virus [J].

Andries, K ;

Moeremans, M ;

Gevers, T ;

Willebrords, R ;

Sommen, C ;

Lacrampe, J ;

Janssens, F ;

Wyde, PR .

ANTIVIRAL RESEARCH, 2003, 60 (03) :209-219

[2] Synthesis and antiviral activity of 7-deazaneplanocin A against orthopoxviruses (vaccinia and cowpox virus) [J].

Arumugham, B ;

Kim, HJ ;

Prichard, MN ;

Kern, ER ;

Chu, CK .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (02) :285-287

[3] Antimicrobial activities of some tetrahydronaphthalene-benzimidazole derivatives [J].

Ates-Alagoz, Zeynep ;

Yildiz, Sulhiye ;

Buyukbingo, Erdem .

CHEMOTHERAPY, 2007, 53 (02) :110-113

[4] INHIBITION OF ENTEROVIRUS CYTOPATHIC EFFECTS BY 2-(ALPHA-HYDROXYBENZYL)-BENZIMIDAZOLE [J].

BABLANIAN, R ;

EGGERS, HJ ;

TAMM, I .

JOURNAL OF BACTERIOLOGY, 1966, 91 (03) :1289-+

[5]

Cappuccino J.G, 1999, Microbiology-a Laboratory Manual, V4th, P263

[6] Synthesis of the 5-phosphono-pent-2-en-1-yl nucleosides: A new class of antiviral acyclic nucleoside phosphonates [J].

Choo, Hyunah ;

Beadle, James R. ;

Chong, Youhoon ;

Trahan, Julissa ;

Hostetler, Karl Y. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2007, 15 (04) :1771-1779

[7] Synthetic studies on novel benzimidazolopeptides with antimicrobial, cytotoxic and anthelmintic potential [J].

Dahiya, Rajiv ;

Pathak, Devender .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2007, 42 (06) :772-798

[8] Anti-enterovirus activity and structure-activity relationship of a series of 2,6-dihalophenyl-substituted 1H,3H-thiazolo[3,4-a]benzimidazoles [J].

De Palma, Armando M. ;

Heggermont, Ward ;

Leyssen, Pieter ;

Puerstinger, Gerhard ;

Wimmer, Eva ;

De Clercq, Erik ;

Rao, Angela ;

Monforte, Anna-Maria ;

Chimirri, Alba ;

Neyts, Johan .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 353 (03) :628-632

[9] Stereoselective synthesis and antifungal activity of (Z)-trans-3-azolyl-2-methylchromanone oxime ethers [J].

Emami, S ;

Falahati, M ;

Banifatemi, A ;

Shafiee, A .

BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (22) :5881-5889

[10] Synthesis and antiviral evaluation of benzimidazoles, quinoxalines and indoles from dehydroabietic acid [J].

Fonseca, T ;

Gigante, B ;

Marques, MM ;

Gilchrist, TL ;

De Clercq, E .

BIOORGANIC & MEDICINAL CHEMISTRY, 2004, 12 (01) :103-112

← 1 2 3 4 5 →