A systematic review and meta-analysis of hypocalciuria in pre-eclampsia

被引:8
作者
McMaster, Kristen M. [1 ]
Kaunitz, Andrew M. [2 ]
de lara, Prardhana Burbano [2 ]
Sanchez-Ramos, Luis [2 ]
机构
[1] Univ Mississippi, Med Ctr, Dept Obstet & Gynecol, Div Maternal Fetal Med, Jackson, MS 39216 USA
[2] Univ Florida, Coll Med Jacksonville, Dept Obstet & Gynecol, Div Maternal Fetal Med, Jacksonville, FL USA
关键词
Calcium excretion; Gestational hypertension; Hypertension; Hypocalciuria; Pre-eclampsia; Urinary calcium; URINARY CALCIUM EXCRETION; PARATHYROID-HORMONE; PREGNANCY; METABOLISM; 1,25-DIHYDROXYVITAMIN-D; HYPERTENSION; MEMBRANE;
D O I
10.1002/ijgo.12165
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Background: Small observational studies have demonstrated that pre-eclampsia is associated with hypocalciuria. Objectives: To compare urinary calcium excretion in pre-eclampsia, gestational hypertension, and chronic hypertension with that in normotensive pregnancies. Search strategy: Online databases were searched through February 2016 using medical subject headings "calcium homeostasis," "calcium excretion," "hypocalciuria," and "pre-eclampsia." Selection criteria: Observational studies were included that evaluated calcium excretion with 24-hour urine collection in patients with pre-eclampsia compared with normotensive pregnant women. Data collection and analysis: Data were extracted from identified studies. The primary outcome was 24-hour urinary calcium excretion. Weighted mean differences (WMDs) with 95% confidence intervals (CIs) were calculated. Main results: Twenty-one studies were included. Urinary calcium excretion was lower among women with pre-eclampsia than among those with normotensive pregnancies (WMD -158.43, 95% CI -187.95 to -128.92) or chronic hypertension (WMD -92.92, 95% CI -100.55 to -85.29). Excretion was also reduced in severe versus mild pre-eclampsia (WMD -35.00, 95% CI -58.94 to -11.07) and gestational hypertension versus normotensive pregnancies (WMD -50.95, 95% CI -57.74 to -44.17). Calcium excretion was not significantly lower in chronic hypertension versus normotensive pregnancies (WMD -64.45, 95% CI -135.98 to 7.08). Conclusions: Urinary calcium excretion decreases with increasing severity of pregnancy-induced hypertensive disorders, but this trend is not observed in chronic hypertension.
引用
收藏
页码:3 / 11
页数:9
相关论文
共 40 条
  • [1] A prospective study for the prediction of preeclampsia with urinary calcium level
    Amitava P.
    Debobroto R.
    Sudhir A.
    Anita R.
    Mandira D.
    Kumar M.A.
    [J]. The Journal of Obstetrics and Gynecology of India, 2012, 62 (3) : 312 - 316
  • [2] Anai T, 1992, Nihon Sanka Fujinka Gakkai Zasshi, V44, P28
  • [3] [Anonymous], BANGLADESH J MED BIO
  • [4] [Anonymous], 2013, Obstet Gynecol, V122, P1122, DOI DOI 10.1097/01.AOG.0000437382.03963.88
  • [5] [Anonymous], J MAT FET MED
  • [6] ABNORMAL 1,25-DIHYDROXYVITAMIN-D METABOLISM IN PREECLAMPSIA
    AUGUST, P
    MARCACCIO, B
    GERTNER, JM
    DRUZIN, ML
    RESNICK, LM
    LARAGH, JH
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1992, 166 (04) : 1295 - 1299
  • [7] THE RELATIONSHIP BETWEEN CALCIUM INTAKE AND PREGNANCY-INDUCED HYPERTENSION - UP-TO-DATE EVIDENCE
    BELIZAN, JM
    VILLAR, J
    REPKE, J
    [J]. AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1988, 158 (04) : 898 - 902
  • [8] The classification and diagnosis of the hypertensive disorders of pregnancy: Statement from the International Society for the Study of Hypertension in Pregnancy (ISSHP)
    Brown, MA
    Lindheimer, MD
    de Swiet, M
    Van Assche, A
    Moutquin, JM
    [J]. HYPERTENSION IN PREGNANCY, 2001, 20 (01) : IX - XIV
  • [9] CALCIUM HOMEOSTASIS AND BONE METABOLISM DURING PREGNANCY, LACTATION, AND POSTWEANING - A LONGITUDINAL-STUDY
    CROSS, NA
    HILLMAN, LS
    ALLEN, SH
    KRAUSE, GF
    VIEIRA, NE
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 1995, 61 (03) : 514 - 523
  • [10] Language bias in randomised controlled trials published in English and German
    Egger, E
    ZellwegerZahner, T
    Schneider, M
    Junker, C
    Lengeler, C
    Antes, G
    [J]. LANCET, 1997, 350 (9074) : 326 - 329