Evaluation of magnetically recyclable nano-Fe3O4 as a green catalyst for the synthesis of mono- and bis-tetrahydro-4H-chromene and mono and bis 1,4-dihydropyridine derivatives

被引：37
|
作者：
Amirheidari, Bagher [1 ]
Seifi, Mohammad [2 ]
Abaszadeh, Mehdi [3 ]
机构：
[1] Kerman Univ Med Sci, Herbal & Tradit Med Res Ctr, Kerman 76175493, Iran
[2] Islamic Azad Univ, Dept Chem, Fac Sci, Najafabad Branch, Najafabad, Esfahan, Iran
[3] Kerman Univ Med Sci, Pharmaceut Res Ctr, Inst Neuropharmacol, Kerman 76175493, Iran
来源：
RESEARCH ON CHEMICAL INTERMEDIATES | 2016年 / 42卷 / 04期
关键词：
Fe3O4; nanoparticles; Tetrahydro-4H-chromenes; 1,4-Dihydropyridines; Three-component reaction; ONE-POT SYNTHESIS; FE3O4; NANOPARTICLES; REUSABLE CATALYST; 3-COMPONENT SYNTHESIS; EFFICIENT; 2-AMINO-4H-CHROMENES; NANOCATALYST; ANTAGONISTS;
D O I：
10.1007/s11164-015-2220-1
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Magnetically separable Fe3O4 nanoparticles were used as an environmental friendly catalyst for the synthesis of mono- and bis-tetrahydro-4H-chromene and mono- and bis-1,4-dihydropyridine derivatives via three-component reactions of aromatic aldehydes and malononitrile with cyclic beta-dicarbonyls or cyclic beta-enaminoketones respectively. These reactions were carried out in EtOH and at reflux. Fe3O4 nanoparticles can be magnetically separated from the reaction mixture by a magnet and recycled without significant loss of catalytic activity.
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页码：3413 / 3423
页数：11
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