Detection of Early Precursors of t(12;21) Positive Pediatric Acute Lymphoblastic Leukemia During Follow-Up

被引：3
作者：
Laszlo, Renata
Alpar, Donat
Kajtar, Bela
Lacza, Agnes
Ottoffy, Gabor [2 ]
Kiss, Csongor [3 ]
Bartyik, Katalin [4 ]
Nagy, Kalman [5 ]
Pajor, Laszlo [1 ]
机构：
[1] Univ Pecs, Dept Pathol, Fac Med, Med Ctr, H-7624 Pecs, Hungary
[2] Univ Pecs, Med Ctr, Dept Pediat Oncol, H-7624 Pecs, Hungary
[3] Univ Debrecen, Med Ctr, Dept Pediat Oncol, H-4012 Debrecen, Hungary
[4] Univ Szeged, Med Ctr, Dept Pediat Oncol, Szeged, Hungary
[5] Borsod Cty Teaching Hosp, Child Welf Ctr, Dept Hematol, Miskolc, Hungary
来源：
PEDIATRIC BLOOD & CANCER | 2010年 / 54卷 / 01期
关键词：
minimal residual disease; pediatric acute lymphoblastic leukemia; real-time quantitative PCR; scanning fluorescence microscopy; t(12; 21) rearrangement; MINIMAL-RESIDUAL-DISEASE; IN-SITU HYBRIDIZATION; GENE REARRANGEMENTS; PCR ANALYSIS; FUSION GENE; TARGETS; IMMUNOGLOBULIN; CELLS;
D O I：
10.1002/pbc.22300
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
DNA-, RNA-, and cell-based methods provide different biologic information for determining the presence of minimal residual disease (MRD). We monitored the responses of patients with pediatric acute lymphoblastic leukemia (PALL) using DNA markers, TEL/AML1 expression, and scanning fluorescence microscopy (SFM). Using SFM, 36% of patients exhibited 1.5-3.1 log and 2.9-4.2 log higher MRD levels compared with those based on DNA and RNA markers, respectively. CD10+ ancestor cells with germline antigen receptors, but silent TEL/AML1 expression, may reside in the lymphoid stem cell compartment of treated t(12;21)-positive patients and might act as a potential source of cells for late relapses. Pediatr Blood Cancer 2010;54:158-160. (C) 2009 Wiley-Liss, Inc.
引用
收藏
页码：158 / 160
页数：3
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