Detection of Early Precursors of t(12;21) Positive Pediatric Acute Lymphoblastic Leukemia During Follow-Up

被引：3
|
作者：
Laszlo, Renata
Alpar, Donat
Kajtar, Bela
Lacza, Agnes
Ottoffy, Gabor [2 ]
Kiss, Csongor [3 ]
Bartyik, Katalin [4 ]
Nagy, Kalman [5 ]
Pajor, Laszlo [1 ]
机构：
[1] Univ Pecs, Dept Pathol, Fac Med, Med Ctr, H-7624 Pecs, Hungary
[2] Univ Pecs, Med Ctr, Dept Pediat Oncol, H-7624 Pecs, Hungary
[3] Univ Debrecen, Med Ctr, Dept Pediat Oncol, H-4012 Debrecen, Hungary
[4] Univ Szeged, Med Ctr, Dept Pediat Oncol, Szeged, Hungary
[5] Borsod Cty Teaching Hosp, Child Welf Ctr, Dept Hematol, Miskolc, Hungary
来源：
PEDIATRIC BLOOD & CANCER | 2010年 / 54卷 / 01期
关键词：
minimal residual disease; pediatric acute lymphoblastic leukemia; real-time quantitative PCR; scanning fluorescence microscopy; t(12; 21) rearrangement; MINIMAL-RESIDUAL-DISEASE; IN-SITU HYBRIDIZATION; GENE REARRANGEMENTS; PCR ANALYSIS; FUSION GENE; TARGETS; IMMUNOGLOBULIN; CELLS;
D O I：
10.1002/pbc.22300
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
DNA-, RNA-, and cell-based methods provide different biologic information for determining the presence of minimal residual disease (MRD). We monitored the responses of patients with pediatric acute lymphoblastic leukemia (PALL) using DNA markers, TEL/AML1 expression, and scanning fluorescence microscopy (SFM). Using SFM, 36% of patients exhibited 1.5-3.1 log and 2.9-4.2 log higher MRD levels compared with those based on DNA and RNA markers, respectively. CD10+ ancestor cells with germline antigen receptors, but silent TEL/AML1 expression, may reside in the lymphoid stem cell compartment of treated t(12;21)-positive patients and might act as a potential source of cells for late relapses. Pediatr Blood Cancer 2010;54:158-160. (C) 2009 Wiley-Liss, Inc.
引用
收藏
页码：158 / 160
页数：3
相关论文
共 44 条
  • [31] An Adult Patient with Early Pre-B Acute Lymphoblastic Leukemia with t(12;17)(p13;q21)/ZNF384-TAF15
    Georgakopoulos, Nikolaos
    Diamantopoulos, Panagiotis
    Micci, Francesca
    Giannakopoulou, Nefeli
    Zervakis, Konstantinos
    Dimitrakopoulou, Aglaia
    Viniou, Nora-Athina
    IN VIVO, 2018, 32 (05): : 1241 - 1245
  • [32] A Double Negative Loop Comprising ETV6/RUNX1 and MIR181A1 Contributes to Differentiation Block in t(12;21)-Positive Acute Lymphoblastic Leukemia
    Yang, Yung-Li
    Yen, Ching-Tzu
    Pai, Chen-Hsueh
    Chen, Hsuan-Yu
    Yu, Sung-Liang
    Lin, Chien-Yu
    Hu, Chung-Yi
    Jou, Shiann-Tarng
    Lin, Dong-Tsamn
    Lin, Shu-Rung
    Lin, Shu-Wha
    PLOS ONE, 2015, 10 (11):
  • [33] CDR3 SIZE ANALYSIS OF T-CELL RECEPTOR-V-BETA TRANSCRIPTS - FOLLOW-UP-STUDY IN A PATIENT WITH T-CELL ACUTE LYMPHOBLASTIC-LEUKEMIA
    PREVOSTBLONDEL, A
    OSTANKOVITCH, M
    MELLE, J
    PANNETIER, C
    MACINTYRE, E
    DREYFUS, F
    GUILLET, JG
    LEUKEMIA, 1995, 9 (10) : 1711 - 1717
  • [34] Faster clinical decisions in B-cell acute lymphoblastic leukaemia: A single flow cytometric 12-colour tube improves diagnosis and minimal residual disease follow-up
    Lebecque, Benjamin
    Besombes, Joevin
    Dannus, Louis-Thomas
    De Antonio, Marie
    Cacheux, Victoria
    Greze, Victoria
    Montagnon, Valentin
    Veronese, Lauren
    Tchirkov, Andrei
    Tournilhac, Olivier
    Berger, Marc G.
    Veyrat-Masson, Richard
    BRITISH JOURNAL OF HAEMATOLOGY, 2024, 204 (05) : 1872 - 1881
  • [35] Clinical relevance of IDH1/2 mutant allele burden during follow-up in acute myeloid leukemia. A study by the French ALFA group
    Ferret, Yann
    Boissel, Nicolas
    Helevaut, Nathalie
    Madic, Jordan
    Nibourel, Olivier
    Marceau-Renaut, Alice
    Bucci, Maxime
    Geffroy, Sandrine
    Celli-Lebras, Karine
    Castaigne, Sylvie
    Thomas, Xavier
    Terre, Christine
    Dombret, Herve
    Preudhomme, Claude
    Renneville, Aline
    HAEMATOLOGICA, 2018, 103 (05) : 822 - 829
  • [36] CENTRAL-NERVOUS-SYSTEM TREATMENT IN CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA - LONG-TERM FOLLOW-UP OF PATIENTS DIAGNOSED BETWEEN 1973 AND 1985
    GELBER, RD
    SALLAN, SE
    COHEN, HJ
    DONNELLY, M
    DALTON, V
    TOBIA, F
    CLAVELL, LA
    TARBELL, NJ
    CANCER, 1993, 72 (01) : 261 - 270
  • [37] Molecular detection of AML1-MTG8-positive cells in peripheral blood from a patient with isolated extramedullary relapse of t(8;21) acute myeloid leukemia
    Tamaki, H.
    Yoshihara, S.
    Fujioka, T.
    Kawakami, M.
    Oka, Y.
    Ogawa, H.
    LEUKEMIA, 2009, 23 (02) : 424 - 426
  • [38] T-cell-rich HLA-haploidentical hematopoietic stem cell transplantation for relapsed/refractory pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia without posttransplant tyrosine kinase inhibitor therapy
    Sano, Hideki
    Mochizuki, Kazuhiro
    Akaihata, Mitsuko
    Kobayashi, Shogo
    Ohto, Hitoshi
    Kikuta, Atsushi
    PEDIATRIC BLOOD & CANCER, 2017, 64 (03)
  • [39] Real-time quantitative reverse transcription-polymerase chain reaction for the detection of AML1-MTG8 fusion transcripts in t(8;21)-positive acute myelogenous leukemia
    Kondo, M
    Kudo, K
    Kimura, H
    Inaba, J
    Kato, K
    Kojima, S
    Matsuyama, T
    Horibe, K
    LEUKEMIA RESEARCH, 2000, 24 (11) : 951 - 956
  • [40] ETV6/RUNX1 transcript is a target of RNA-binding protein IGF2BP1 in t(12;21)(p13;q22)-positive acute lymphoblastic leukemia
    Stoskus, Mindaugas
    Vaitkeviciene, Goda
    Eidukaite, Audrone
    Griskevicius, Laimonas
    BLOOD CELLS MOLECULES AND DISEASES, 2016, 57 : 30 - 34
12345