Energetics in the pathogenesis of neurodegenerative diseases

被引:405
作者
Beal, MF [1 ]
机构
[1] Cornell Univ, Weill Med Coll, Dept Neurol & Neurosurg, New York, NY 10021 USA
[2] New York Hosp, Weill Cornell Med Ctr, New York, NY 10021 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/S0166-2236(00)01584-8
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Mitochondria have been linked to both necrotic and apoptotic cell death, which are thought to have a major role in the pathogenesis of neurodegenerative diseases. Recent evidence shows that nuclear gene defects affecting mitochondrial function have a role in the pathogenesis of Friedreich's ataxia, Wilson's disease and hereditary spastic paraplegia. There is also accumulating evidence that mitochondrial dysfunction might have a role in the pathogenesis of amyotrophic lateral sclerosis, Huntington's disease, Parkinson's disease and Alzheimer's disease. If this is so, a number of therapeutic targets ave implicated that might result in novel treatments for neurodegenerative diseases.
引用
收藏
页码:298 / 304
页数:7
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