Progress towards the total synthesis of trichodermamides A and B:: Construction of the oxazine ring moiety

被引：25

作者：

Wan, Xiaobo ^{[1
]}

Doridot, Gabriel ^{[1
]}

Joullie, Madeleine M. ^{[1
]}

机构：

[1] Univ Penn, Dept Chem, Philadelphia, PA 19104 USA

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 06期

关键词：

D O I：

10.1021/ol062993x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Trichodermamides are modified heterocyclic dipeptides that possess a unique 4H-5,6-dihydro-1,2-oxazine ring. Starting from affordable, easily available (-)-quinic acid, the enantioselective synthesis of this oxazine moiety was achieved by an intramolecular epoxide ring-opening reaction by an oxime.

引用

页码：977 / 980

页数：4

共 21 条

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