Differential Immune Profiles in Two Pandemic Influenza A(H1N1)pdm09 Virus Waves at Pandemic Epicenter

被引：8

作者：

Arriaga-Pizano, Lourdes ^{[1
]}

Ferat-Osorio, Eduardo ^{[1
,2
]}

Rodriguez-Abrego, Gabriela ^{[3
]}

Manilla-Herrera, Ismael ^{[4
]}

Dominguez-Cerezo, Esteban ^{[1
,6
]}

Valero-Pacheco, Nuriban ^{[1
,6
]}

Perez-Toledo, Marisol ^{[1
,6
]}

Lozano-Patino, Fernando ^{[7
]}

Laredo-Sanchez, Fernando ^{[7
]}

Malagon-Rangel, Jose ^{[7
]}

Nellen-Hummel, Haiko ^{[7
]}

Gonzalez-Bonilla, Cesar ^{[8
]}

Arteaga-Troncoso, Gabriel ^{[5
]}

Cerbulo-Vazquez, Arturo ^{[9
]}

Pastelin-Palacios, Rodolfo ^{[10
]}

Klenerman, Paul ^{[11
,12
]}

Isibasi, Armando ^{[1
]}

Lopez-Macias, Constantino ^{[1
]}

机构：

[1] Natl Med Ctr Siglo XXI, Specialties Hosp, IMSS, Med Res Unit Immunochem, Mexico City, DF, Mexico

[2] Specialties Hosp, Natl Med Ctr Siglo 21, IMSS, Gastrointestinal Surg Serv, Mexico City, DF, Mexico

[3] IMSS, Clin Epidemiol Serv, Reg Hosp 1, Mexico City, DF, Mexico

[4] Natl Inst Perinatol, SSA, Infectol & Immunol Dept, Mexico City, DF, Mexico

[5] Natl Inst Perinatol, SSA, Cellular Biol Dept, Mexico City, DF, Mexico

[6] IPN, Grad Program Immunol, ENCB, Mexico City, DF, Mexico

[7] Natl Med Ctr Siglo XXI, Specialties Hosp, Internal Med Serv, IMSS, Mexico City, DF, Mexico

[8] Natl Med Ctr La Raza, Unit Epidemiol Surveillance, IMSS, Mexico City, DF, Mexico

[9] Womans Hosp, Div Res & Educ, Minist Hlth, Mexico City, DF, Mexico

[10] Natl Autonomous Univ Mexico UNAM, Fac Chem, Mexico City, DF, Mexico

[11] Univ Oxford, Oxford Biomed Res Ctr, Oxford, England

[12] Univ Oxford, Nuffield Dept Med, Oxford Martin Sch, Oxford, England

来源：

ARCHIVES OF MEDICAL RESEARCH | 2015年 / 46卷 / 08期

关键词：

Immune profiles; Pandemic A(H1N1)pdm2009 influenza; Pandemic waves; T-CELL RESPONSES; H1N1; INFLUENZA; DENDRITIC CELLS; INFECTION; INFLAMMATION; EXPRESSION; MONOCYTES; TRANSMISSIBILITY; VACCINATION; NEUTROPHILS;

D O I：

10.1016/j.arcmed.2015.12.003

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Background and Aims. Severe influenza A(H1N1)pdm2009 virus infection cases are characterized by sustained immune activation during influenza pandemics. Seasonal flu data suggest that immune mediators could be modified by wave-related changes. Our aim was to determine the behavior of soluble and cell-related mediators in two waves at the epicenter of the 2009 influenza pandemic. Methods. Leukocyte surface activation markers were studied in serum from peripheral blood samples, collected from the 1st (April May, 2009) and 2nd (October 2009 February 2010) pandemic waves. Patients with confirmed influenza A(H1N1) pdm2009 virus infection (H1N1), influenza-like illness (ILI) or healthy donors (H) were analyzed. Results. Serum IL-6, IL-4 and IL-10 levels were elevated in H1N1 patients from the 2nd pandemic wave. Additionally, the frequency of helper and cytotoxic T cells was reduced during the 1st wave, whereas CD69 expression in helper T cells was increased in the 2nd wave for both H1N1 and ILI patients. In contrast, CD62L expression in granulocytes from the ILI group was increased in both waves but in monocytes only in the 2nd wave. Triggering Receptor Expressed on Myeloid cells (TREM)-1 expression was elevated only in H1N1 patients at the 1st wave. Conclusions. Our results show that during the 2009 influenza pandemic a T cell activation phenotype is observed in a wave-dependent fashion, with an expanded activation in the 2nd wave, compared to the 1st wave. Conversely, granulocyte and monocyte activation is infection-dependent. This evidence collected at the pandemic epicenter in 2009 could

引用

页码：651 / 658

页数：8

共 62 条

[1] TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection [J].

Aldridge, Jerry R., Jr. ;

Moseley, Carson E. ;

Boltz, David A. ;

Negovetich, Nicholas J. ;

Reynolds, Cory ;

Franks, John ;

Brown, Scott A. ;

Doherty, Peter C. ;

Webster, Robert G. ;

Thomas, Paul G. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (13) :5306-5311

[2]

[Anonymous], 2009, CDC protocol of realtime RTPCR for influenza A(H1N1)

[3]

[Anonymous], 2012, WHO PANDEMINC H1N1 2

[4] Early and sustained innate immune response defines pathology and death in nonhuman primates infected by highly pathogenic influenza virus [J].

Baskin, Carole R. ;

Bielefeldt-Ohmann, Helle ;

Tumpey, Terrence M. ;

Sabourin, Patrick J. ;

Long, James P. ;

Garcia-Sastre, Adolfo ;

Tolnay, Airn-E. ;

Albrecht, Randy ;

Pyles, John A. ;

Olson, Pam H. ;

Aicher, Lauri D. ;

Rosenzweig, Elizabeth R. ;

Murali-Krishna, Kaja ;

Clark, Edward A. ;

Kotur, Mark S. ;

Fornek, Jamie L. ;

Proll, Sean ;

Palermo, Robert E. ;

Sabourin, Carol L. ;

Katze, Michael G. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (09) :3455-3460

[5] THE RESPONSE TO H-2-DIFFERENT VIRUS-INFECTED CELLS IS MEDIATED BY LONG-LIVED LYMPHOCYTES-T AND IS DIMINISHED BY PRIOR VIRUS PRIMING IN A SYNGENEIC ENVIRONMENT [J].

BENNINK, JR ;

DOHERTY, PC .

CELLULAR IMMUNOLOGY, 1981, 61 (01) :220-224

[6] The influence of changing host immunity on 1918-19 pandemic dynamics [J].

Bolton, K. J. ;

McCaw, J. M. ;

McVernon, J. ;

Mathews, J. D. .

EPIDEMICS, 2014, 8 :18-27

[7] DEFINITIONS FOR SEPSIS AND ORGAN FAILURE AND GUIDELINES FOR THE USE OF INNOVATIVE THERAPIES IN SEPSIS [J].

BONE, RC ;

BALK, RA ;

CERRA, FB ;

DELLINGER, RP ;

FEIN, AM ;

KNAUS, WA ;

SCHEIN, RMH ;

SIBBALD, WJ .

CHEST, 1992, 101 (06) :1644-1655

[8] Local IL-4 expression in the lung reduces pulmonary influenza-virus-specific secondary cytotoxic T cell responses [J].

Bot, A ;

Holz, A ;

Christen, U ;

Wolfe, T ;

Temann, A ;

Flavell, R ;

von Herrath, M .

VIROLOGY, 2000, 269 (01) :66-77

[9] A Systems Analysis Identifies a Feedforward Inflammatory Circuit Leading to Lethal Influenza Infection [J].

Brandes, Marlene ;

Klauschen, Frederick ;

Kuchen, Stefan ;

Germain, Ronald N. .

CELL, 2013, 154 (01) :197-212

[10] Does homologous reinfection drive multiple-wave influenza outbreaks? Accounting for immunodynamics in epidemiological models [J].

Camacho, A. ;

Cazelles, B. .

EPIDEMICS, 2013, 5 (04) :187-196

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