Intracranial Hemorrhage Following Oral Low-Dose Methotrexate After Multiple Toxicities Caused by High-Dose Methotrexate in Childhood Acute Lymphoblastic Leukemia

被引：5
作者：
Ning Xin [1 ]
Zhou Fen [1 ]
Cheng Li [1 ]
Xiao Yan [1 ]
Jin Runming [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Pediat, Wuhan, Hubei, Peoples R China
来源：
FRONTIERS IN PHARMACOLOGY | 2019年 / 10卷
关键词：
intracranial hemorrhage; methotrexate; toxicity; neurotoxicity; acute lymphoblastic leukemia; THERAPY; IKZF1; CHILDREN; DELETION;
D O I：
10.3389/fphar.2019.01072
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
An 11-year-old male patient with the deletion of IKZF1 (Ikaros family zinc finger 1) and positive Breakpoint Cluster Region-C-Abelson oncogene 1(BCR-ABL1) acute lymphoblastic leukemia developed mucositis, gastrointestinal toxicity, hepatotoxicity, myelosuppression, and severe dermatologic toxicity during the first and second courses of high-dose methotrexate. The patient recovered completely after therapy. However, intracranial hemorrhage (ICH) occurred following oral methotrexate at a dose of 25 mg/m(2) in maintenance treatment, and he had neurological sequelae including hemiplegic paralysis.
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页数：7
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