Design, Synthesis and Anticancer Activity of 1,2,4-Thiadiazole Derivatives Bearing 1,2,4-Oxadiazole

被引：5

作者：

Sudhakar, D. G. S. ^{[1
,2
]}

Rao, A. Srinivasa ^{[1
]}

Reddy, Ch Venkata Ramana ^{[2
]}

机构：

[1] GVK Biosci Private Ltd, Med Chem Div, 28A, Hyderabad 500076, Telangana, India

[2] Jawaharlal Nehru Technol Univ, Dept Chem, Hyderabad 500085, Telangana, India

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2019年 / 89卷 / 08期

关键词：

Cefozopram; KC; 12291; ataluren; anticancer activity; CARDIOPROTECTIVE ACTIONS; KC; 12291;

D O I：

10.1134/S1070363219080243

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of novel 1,2,4-thiadiazole derivatives bearing 1,2,4-oxadiazole is synthesized. Structures of the synthesized compounds are confirmed by H-1 and C-13 NMR, and mass spectra. All products are evaluated for their anticancer activity towards human cancer cell lines: MCF-7 (breast), A549 (lung), Colo-205 (colon), and A2780 (ovarian), and demonstrate good to moderate anticancer activity. Four synthesized compounds are characterised by potent activity.

引用

页码：1696 / 1701

页数：6

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