A new function for p53 ubiquitination

被引：12
作者：
Hirano, Yuko [1 ]
Ronai, Ze'ev [1 ]
机构：
[1] Burnham Inst Med Res, La Jolla, CA 92130 USA
来源：
CELL | 2006年 / 127卷 / 04期
关键词：
D O I：
10.1016/j.cell.2006.11.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The amount of p53 protein in a cell is normally limited by ubiquitin-dependent degradation. In this issue of Cell, Le Cam et al. (2006) reveal that p53 ubiquitination contributes to transcriptional activation rather than protein stability. These results may provide insight into how p53 can modulate diverse cellular processes such as growth arrest and apoptosis.
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收藏
页码：675 / 677
页数：3
相关论文
共 11 条
[1]   p53 ubiquitination: Mdm2 and beyond [J].
Brooks, CL ;
Gu, W .
MOLECULAR CELL, 2006, 21 (03) :307-315
[2]   The proteasome: a utility tool for transcription? [J].
Collins, GA ;
Tansey, WP .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2006, 16 (02) :197-202
[3]  
Fuchs SY, 1999, MOL CELL BIOL, V19, P3289
[4]   Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1 [J].
Laine, A. ;
Ronai, Z. .
ONCOGENE, 2007, 26 (10) :1477-1483
[5]   Regulation of p53 localization and activity by Ubc13 [J].
Laine, Aaron ;
Topisirovic, Ivan ;
Zhai, Dayong ;
Reed, John C. ;
Borden, Katherine L. B. ;
Ronai, Ze'ev .
MOLECULAR AND CELLULAR BIOLOGY, 2006, 26 (23) :8901-8913
[6]   A CELLULAR PROTEIN, ACTIVATING TRANSCRIPTION FACTOR, ACTIVATES TRANSCRIPTION OF MULTIPLE E1A-INDUCIBLE ADENOVIRUS EARLY PROMOTERS [J].
LEE, KAW ;
HAI, TY ;
SIVARAMAN, L ;
THIMMAPPAYA, B ;
HURST, HC ;
JONES, NC ;
GREEN, MR .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (23) :8355-8359
[7]   The E6AP ubiquitin ligase is required for transactivation of the hTERT promoter by the human papillomavirus E6 oncoprotein [J].
Liu, XF ;
Yuan, H ;
Fu, BJ ;
Disbrow, GL ;
Apolinario, T ;
Tomaic, V ;
Kelley, ML ;
Baker, CC ;
Huibregtse, J ;
Schlegel, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (11) :10807-10816
[8]   hnRNP K: An HDM2 target and transcriptional coactivator of p53 in response to DNA damage [J].
Moumen, A ;
Masterson, P ;
O'Connor, MJ ;
Jackson, SP .
CELL, 2005, 123 (06) :1065-1078
[9]   Phosphorylation and ubiquitination of the transcription factor sterol regulatory element-binding protein-1 in response to DNA binding [J].
Punga, Tanel ;
Bengoechea-Alonso, Maria T. ;
Ericsson, Johan .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (35) :25278-25286
[10]   p53 stabilization and transactivation by a von Hippel-Lindau protein [J].
Roe, Jae-Seok ;
Kim, Hyungsoo ;
Lee, Soon-Min ;
Kim, Sung-Tae ;
Cho, Eun-Jung ;
Youn, Hong-Duk .
MOLECULAR CELL, 2006, 22 (03) :395-405
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