Pharmacogenomics

被引：259

作者：

Roden, Dan M. ^{[1
,2
,3
]}

McLeod, Howard L. ^{[5
]}

Relling, Mary V. ^{[6
]}

Williams, Marc S. ^{[7
]}

Mensah, George A. ^{[8
]}

Peterson, Josh F. ^{[1
,3
]}

Van Driest, Sara L. ^{[1
,4
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Med, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Med Ctr, Dept Pharmacol, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Med Ctr, Dept Biomed Informat, Nashville, TN USA

[4] Vanderbilt Univ, Med Ctr, Dept Pediat, Nashville, TN 37232 USA

[5] H Lee Moffitt Canc Ctr & Res Inst, DeBartolo Family Personalized Med Inst, Tampa, FL USA

[6] St Jude Childrens Res Hosp, Pharmaceut Dept, 332 N Lauderdale St, Memphis, TN 38105 USA

[7] Geisinger, Genom Med Inst, Danville, PA USA

[8] NHLBI, Ctr Translat Res, NIH, Bldg 10, Bethesda, MD 20892 USA

来源：

LANCET | 2019年 / 394卷 / 10197期

关键词：

ADVERSE DRUG-REACTIONS; CONSORTIUM CPIC GUIDELINES; GENOME-WIDE ASSOCIATION; OF-FUNCTION MUTATIONS; IMPLEMENTATION CONSORTIUM; COST-EFFECTIVENESS; GENETIC-VARIANTS; PERSONALIZED MEDICINE; CYP2C19; GENOTYPE; RANDOMIZED-TRIAL;

D O I：

10.1016/S0140-6736(19)31276-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Genomic medicine, which uses DNA variation to individualise and improve human health, is the subject of this Series of papers. The idea that genetic variation can be used to individualise drug therapy-the topic addressed here-is often viewed as within reach for genomic medicine. We have reviewed general mechanisms underlying variability in drug action, the role of genetic variation in mediating beneficial and adverse effects through variable drug concentrations (pharmacokinetics) and drug actions (pharmacodynamics), available data from clinical trials, and ongoing efforts to implement pharmacogenetics in clinical practice.

引用

页码：521 / 532

页数：12

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