The Ontario Neurodegenerative Disease Research Initiative (ONDRI)

被引：68

作者：

Farhan, Sali M. K. ^{[1
,2
]}

Bartha, Robert ^{[2
,3
]}

Black, Sandra E. ^{[4
,5
]}

Corbett, Dale ^{[6
]}

Finger, Elizabeth ^{[7
]}

Freedman, Morris ^{[8
,9
]}

Greenberg, Barry ^{[10
]}

Grimes, David A. ^{[11
]}

Hegele, Robert A. ^{[1
,2
]}

Hudson, Chris ^{[12
]}

Kleinstiver, Peter W. ^{[13
]}

Lang, Anthony E. ^{[14
,15
,16
]}

Masellis, Mario ^{[4
]}

McIlroy, William E. ^{[17
]}

McLaughlin, Paula M. ^{[13
]}

Montero-Odasso, Manuel ^{[18
]}

Munoz, David G. ^{[19
]}

Munoz, Douglas P. ^{[20
]}

Strother, Stephen ^{[21
]}

Swartz, Richard H. ^{[22
]}

Symons, Sean ^{[23
]}

Tartaglia, Maria Carmela ^{[24
,25
]}

Zinman, Lorne ^{[4
]}

Strong, Michael J. ^{[2
,7
]}

机构：

[1] Western Univ, Schulich Sch Med & Dent, Dept Biochem, London, ON, Canada

[2] Western Univ, Robarts Res Inst, London, ON, Canada

[3] Western Univ, Schulich Sch Med & Dent, Dept Med Biophys, London, ON, Canada

[4] Univ Toronto, Sunnybrook Hlth Sci Ctr, Sunnybrook Res Inst,Hurvitz Brain Sci Res Program, Dept Med Neurol,LC Campbell Cognit Neurol Res Uni, Toronto, ON, Canada

[5] Univ Toronto, Sunnybrook Hlth Sci Ctr, Canadian Partnership Stroke Recovery Sunnybrook S, Toronto, ON M5S 1A1, Canada

[6] Univ Ottawa, Fac Med, Dept Cellular & Mol Med, Ottawa, ON, Canada

[7] Western Univ, Schulich Sch Med & Dent, Dept Clin Neurol Sci, London, ON, Canada

[8] Baycrest Hlth Sci & Univ Toronto, Dept Med Neurol, Toronto, ON, Canada

[9] Rotman Res Inst, Baycrest Ctr Geriatr Care, Toronto, ON, Canada

[10] Univ Hlth Network, Toronto Dementia Res Alliance, Toronto, ON, Canada

[11] Univ Ottawa, Ottawa Hosp, Fac Med, Dept Med, Ottawa, ON, Canada

[12] Univ Waterloo, Sch Optometry & Vis Sci, Waterloo, ON, Canada

[13] Western Univ, Schulich Sch Med & Dent, London, ON, Canada

[14] Univ Toronto, Morton & Gloria Shulman Movement Disorders Clin, Toronto, ON, Canada

[15] Univ Toronto, Toronto Western Hosp, Edmond J Safra Program Parkinsons Dis, Toronto, ON, Canada

[16] Univ Toronto, Dept Med, Toronto, ON, Canada

[17] Univ Waterloo, Dept Kinesiol, Waterloo, ON, Canada

[18] Schulich Sch Med & Dent, Dept Med Geriatr & Epidemiol & Biostat, Gait & Brain Lab, London, ON, Canada

[19] Univ Toronto, St Michaels Hosp, Keenan Res Ctr Biomed Sci, Div Pathol,Lab Med & Pathobiol, Toronto, ON, Canada

[20] Queens Univ, Ctr Neurosci Studies, Kingston, ON, Canada

[21] Univ Toronto, Rotman Res Inst, Dept Med Biophys, Baycrest, Toronto, ON, Canada

[22] Univ Toronto, Fac Med,Hurvitz Brain Sci Res Program, Sunnybrook Hlth Sci Ctr,LC Campbell Cognit Neurol, Sunnybrook Res Inst,Inst Med Sci,Dept Med Neurol, Toronto, ON, Canada

[23] Sunnybrook Hlth Sci Ctr, Dept Med Imaging, Toronto, ON, Canada

[24] Univ Toronto, Div Neurol, Toronto, ON, Canada

[25] Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Dept Med, Toronto, ON, Canada

来源：

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES | 2017年 / 44卷 / 02期

基金：

加拿大健康研究院;

关键词：

Neurodegeneration; Dementia; Alzheimer's; Amyotrophic Lateral Sclerosis; Frontotemporal Dementia; Parkinson Disease; vascular cognitive impairment; MILD COGNITIVE IMPAIRMENT; STROKE-CANADIAN STROKE; ALZHEIMERS-DISEASE; NATIONAL INSTITUTE; NEUROLOGICAL DISORDERS; APOE EPSILON-4; DUAL-TASK; DEMENTIA; PEOPLE; RISK;

D O I：

10.1017/cjn.2016.415

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Because individuals develop dementia as a manifestation of neurodegenerative or neurovascular disorder, there is a need to develop reliable approaches to their identification. We are undertaking an observational study (Ontario Neurodegenerative Disease Research Initiative [ONDRI]) that includes genomics, neuroimaging, and assessments of cognition as well as language, speech, gait, retinal imaging, and eye tracking. Disorders studied include Alzheimer's disease, amyotrophic lateral sclerosis, frontotemporal dementia, Parkinson's disease, and vascular cognitive impairment. Data from ONDRI will be collected into the Brain-CODE database to facilitate correlative analysis. ONDRI will provide a repertoire of endophenotyped individuals that will be a unique, publicly available resource.

引用

页码：196 / 202

页数：7

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