Phytochemical and pharmacological studies on Leonotis leonurus

被引：23

作者：

El-Ansari, Mohamed A. ^{[1
]}

Aboutabl, ElSayed A. ^{[2
]}

Farrag, Abdel Razik H. ^{[3
]}

Sharaf, Mohammed ^{[1
]}

Hawas, Usama W. ^{[1
]}

Soliman, Ghadir A. ^{[1
]}

El-Seed, Gamila S. ^{[4
]}

机构：

[1] Natl Res Ctr, Phytochem & Plant Systemat Dept, Cairo 12311, Egypt

[2] Cairo Univ, Fac Pharm, Dept Pharmacognosy, Cairo, Egypt

[3] Natl Res Ctr, Dept Pathol, Cairo 12311, Egypt

[4] Natl Res Ctr, Dept Med Biochem, Cairo 12311, Egypt

来源：

PHARMACEUTICAL BIOLOGY | 2009年 / 47卷 / 09期

关键词：

Anti-inflammatory activity; flavonoids; hepatoprotective activity; Lamiaceae; Leonotis leonurus; NMR; INDUCED HEPATIC NECROSIS; HEPATOPROTECTIVE ACTIVITY; MEDICINAL-PLANTS; PARACETAMOL; RATS; ACETAMINOPHEN; DAMAGE; INTOXICATION; DISPOSITION; PREVENTION;

D O I：

10.1080/13880200902942428

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The present study aimed at isolation of the flavonoid constituents of Leonotis leonurus R. Br. (Lamiaceae) flowering aerial parts, identification of the isolated compounds, and evaluation of the hepatoprotective, anti-inflammatory and cytotoxic activities of the aqueous alcoholic and chloroform extracts. Isolation of the flavonoid constituents was performed using chromatographic techniques. Ten flavonoid compounds were isolated and identified as six flavone glycosides, two methylated flavones, and two flavone aglycons. The structures were established through chemical and spectral analysis. Paracetamol-incluced hepatotoxicity, carrageenan-induced hind rat paw edema and sulforhodamine B (SRB) assay were used in the evaluation of hepatoprotective, anti-inflammatory and cytotoxic activities, respectively. The 70% methanol and chloroform extracts showed strong hepatoprotective and anti-inflammatory activity; no cytotoxic activity was observed at the chosen extract concentrations and they possess promising protective activity against paracetamol-incluced hepatic damage and anti-inflammatory activity in rats. The flavonoids isolated from Leonotis leonurus in this study were found to be isolated for the first time from the genus Leonotis.

引用

页码：894 / 902

页数：9

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