Long non-coding RNAs in innate and adaptive immunity

被引：69

作者：

Aune, Thomas M. ^{[1
]}

Spurlock, Charles F., III ^{[1
]}

机构：

[1] Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37212 USA

来源：

VIRUS RESEARCH | 2016年 / 212卷

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

Long non-coding RNA; Whole genome RNA-sequencing; Immune system; Epigenetics; Transcriptional regulation; DIFFERENTIAL EXPRESSION ANALYSIS; T-CELL DEVELOPMENT; TRANSCRIPTION FACTOR; DENDRITIC CELLS; INTERFERON-GAMMA; GENE-EXPRESSION; QUALITY-CONTROL; SEQUENCE; REVEALS; GENOMICS;

D O I：

10.1016/j.virusres.2015.07.003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Long noncoding RNAs (IncRNAs) represent a newly discovered class of regulatory molecules that impact a variety of biological processes in cells and organ systems. In humans, it is estimated that there may be more than twice as many IncRNA genes than protein-coding genes. However, only a handful of IncRNAs have been analyzed in detail. In this review, we describe expression and functions of IncRNAs that have been demonstrated to impact innate and adaptive immunity. These emerging paradigms illustrate remarkably diverse mechanisms that IncRNAs utilize to impact the transcriptional programs of immune cells required to fight against pathogens and maintain normal health and homeostasis. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：146 / 160

页数：15

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