Application of Deep Eutectic Solvents for the Extraction of Carnosic Acid and Carnosol from Sage (Salvia officinalis L.) with Response Surface Methodology Optimization

被引:11
作者
Jakovljevic, Martina [1 ]
Jokic, Stela [1 ]
Molnar, Maja [1 ]
Jerkovic, Igor [2 ]
机构
[1] Josip Juraj Strossmayer Univ Osijek, Fac Food Technol Osijek, Franje Kuhaca 18, Osijek 31000, Croatia
[2] Univ Split, Fac Chem & Technol, Rudera Boskovica 35, Split 21000, Croatia
来源
PLANTS-BASEL | 2021年 / 10卷 / 01期
关键词
sage; optimization; stirring and heating extraction; ultrasound-assisted extraction; mechanochemical extraction;
D O I
10.3390/plants10010080
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Salvia officinalis L. is a good source of antioxidant compounds such as phenolic diterpenes carnosic acid and carnosol. From 17 deep eutectic solvents (DESs) used, choline chloride: lactic acid (1:2 molar ratio) was found to be the most suitable for the extraction of targeted compounds. The influence of H2O content, extraction time, and temperature (for stirring and heating and for ultrasound-assisted extraction (UAE)), H2O content, extraction time, and vibration speed for mechanochemical extraction on the content of targeted compounds were investigated. Carnosic acid content obtained by the extraction assisted by stirring and heating was from 2.55 +/- 0.04 to 14.43 +/- 0.28 mu g mg(-1), for UAE it was from 1.62 +/- 0.29 to 14.00 +/- 0.02 mu g mg(-1), and for mechanochemical extraction the yield was from 1.80 +/- 0.02 to 8.26 +/- 0.45 mu g mg(-1). Determined carnosol content was in the range 0.81 +/- 0.01 to 4.83 +/- 0.09 mu g mg(-1) for the extraction with stirring and for UAE it was from 0.56 +/- 0.02 to 4.18 +/- 0.05 mu g mg(-1), and for mechanochemical extraction the yield was from 0.57 +/- 0.11 to 2.01 +/- 0.16 mu g mg(-1). Optimal extraction conditions determined by response surface methodology (RSM) were in accordance with experimentally demonstrated values. In comparison with previously published or own results using conventional solvents or supercritical CO2, used DES provided more efficient extraction of both targeted compounds.
引用
收藏
页码:1 / 20
页数:20
相关论文
共 37 条
  • [1] Deep eutectic solvents formed between choline chloride and carboxylic acids: Versatile alternatives to ionic liquids
    Abbott, AP
    Boothby, D
    Capper, G
    Davies, DL
    Rasheed, RK
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (29) : 9142 - 9147
  • [2] Novel solvent properties of choline chloride/urea mixtures
    Abbott, AP
    Capper, G
    Davies, DL
    Rasheed, RK
    Tambyrajah, V
    [J]. CHEMICAL COMMUNICATIONS, 2003, (01) : 70 - 71
  • [3] Phenolic diterpene and α-tocopherol contents in leaf extracts of 60 Salvia species
    Abreu, Maria E.
    Muller, Maren
    Alegre, Leonor
    Munne-Bosch, Sergi
    [J]. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 2008, 88 (15) : 2648 - 2653
  • [4] ANTIOXIDANT AND PROOXIDANT PROPERTIES OF ACTIVE ROSEMARY CONSTITUENTS - CARNOSOL AND CARNOSIC ACID
    ARUOMA, OI
    HALLIWELL, B
    AESCHBACH, R
    LOLIGERS, J
    [J]. XENOBIOTICA, 1992, 22 (02) : 257 - 268
  • [5] Supercritical carbon dioxide extraction of antioxidant fractions from selected Lamiaceae herbs and their antioxidant capacity
    Babovic, Nada
    Djilas, Sonja
    Jadranin, Milka
    Vajs, Vlatka
    Ivanovic, Jasna
    Petrovic, Slobodan
    Zizovic, Irena
    [J]. INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES, 2010, 11 (01) : 98 - 107
  • [6] Novel lactic acid-based natural deep eutectic solvents: Efficiency in the ultrasound-assisted extraction of antioxidant polyphenols from common native Greek medicinal plants
    Bakirtzi, Christina
    Triantafyllidou, Katerina
    Makris, Dimitris P.
    [J]. JOURNAL OF APPLIED RESEARCH ON MEDICINAL AND AROMATIC PLANTS, 2016, 3 (03) : 120 - 127
  • [7] Modeling and optimization I: Usability of response surface methodology
    Bas, Deniz
    Boyaci, Ismail H.
    [J]. JOURNAL OF FOOD ENGINEERING, 2007, 78 (03) : 836 - 845
  • [8] Evaluation of alcohol-based deep eutectic solvent in extraction and determination of flavonoids with response surface methodology optimization
    Bi, Wentao
    Tian, Minglei
    Row, Kyung Ho
    [J]. JOURNAL OF CHROMATOGRAPHY A, 2013, 1285 : 22 - 30
  • [9] Natural deep eutectic solvents and ultrasound-assisted extraction: Green approaches for extraction of wine lees anthocyanins
    Bosiljkov, Tomislau
    Dujmic, Filip
    Bubalo, Marina Cujetko
    Hribar, Janez
    Vidrih, Rajko
    Brncic, Mladen
    Zlatic, Emil
    Redovnikavic, Ivana Radojclc
    Jokic, Stela
    [J]. FOOD AND BIOPRODUCTS PROCESSING, 2017, 102 : 195 - 203
  • [10] New perspective in extraction of plant biologically active compounds by green solvents
    Bubalo, Marina Cvjetko
    Vidovic, Senka
    Redovnikovic, Ivana Radojcic
    Jokic, Stela
    [J]. FOOD AND BIOPRODUCTS PROCESSING, 2018, 109 : 52 - 73