On the restriction of the release of water-soluble component from polyvinyl alcohol film by blending beta-cyclodextrin

The effect of adding beta-Cyclodextrin with poly(vinyl alcohol) (PVA) hydrogel on the release of a water-soluble component has been investigated. It is found that the release of a model drug, salicyclic acid, from PVA matrix in the presence of beta-cyclodextrin prolonged considerably the release of the profile of the drug from the PVA gel. The profound influence of beta-cyclodextrin on the drug release has been assigned to the ability of beta-cyclodextrin to form an inclusion complex with salicyclic acid. (C) 1997 John Wiley & Sons, Inc.