Value added: functional MR imaging in management of bone and soft tissue sarcomas

被引:22
作者
Subhawong, Ty K. [1 ]
Wilky, Breelyn A. [2 ]
机构
[1] Univ Miami, Dept Radiol, Miller Sch Med, Jackson Mem Hosp, Miami, FL USA
[2] Univ Miami, Div Hematol Oncol, Dept Med, Miller Sch Med,Sylvester Comprehens Canc Ctr, Miami, FL USA
关键词
clinical trial; dynamic contrast enhanced; diffusion-weighted imaging; functional MRI; sarcoma; DIFFUSION-WEIGHTED MRI; RESPONSE EVALUATION CRITERIA; ISOLATED LIMB PERFUSION; MUSCULOSKELETAL LESIONS; HISTOLOGIC RESPONSE; TUMOR RESPONSE; SOLID TUMORS; NEOADJUVANT CHEMOTHERAPY; INITIAL-EXPERIENCE; CHOI CRITERIA;
D O I
10.1097/CCO.0000000000000199
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose of review MRI plays a crucial role in the initial diagnosis, treatment planning, and long-term management of bone and soft tissue sarcomas. Technological advances have enabled improvements in both delineation of anatomic detail, and in functional imaging techniques that interrogate tissues at the cellular level. This bears particular relevance in sarcomas as morphological parameters alone do not necessarily correlate with treatment response and prognosis. Here, we describe recent developments in advanced MRI techniques, including chemical-shift MRI, diffusion-weighted imaging (DWI), MR spectroscopy (MRS), and dynamic contrast enhanced (DCE) MRI. Recent findings Chemical-shift MRI allows robust discrimination of marrow infiltrating neoplasms from benign red marrow. DWI reveals tumor cellularity, and aids in distinguishing benign and malignant tumors along with the assessment of treatment response. MRS is technically challenging in the musculoskeletal system, but shows promise as a means to noninvasively assess metabolic aberrations in a variety of sarcomas. DCE is particularly suited to treatment response evaluation, in which traditional size-based assessment criteria may underestimate efficacy in clinical trials. Summary Functional MRI techniques offer novel imaging biomarkers that effectively complement conventional MRI in the assessment of bone and soft tissue sarcomas at all stages of patient care.
引用
收藏
页码:323 / 331
页数:9
相关论文
共 50 条
  • [41] PET/MR imaging of sarcomas: effect of PET quantification by classification of tissue
    Claes Nøhr Ladefoged
    Adam Espe Hansen
    Kim Francis Andersen
    Annika Loft
    Liselotte Højgaard
    Andreas Kjær
    Flemming Andersen
    EJNMMI Physics, 1 (Suppl 1)
  • [42] SOFT-TISSUE SARCOMAS - USE OF TEXTURAL PATTERNS IN SKELETAL-MUSCLE AS A DIAGNOSTIC FEATURE IN POSTOPERATIVE MR IMAGING
    BIONDETTI, PR
    EHMAN, RL
    RADIOLOGY, 1992, 183 (03) : 845 - 848
  • [43] Expression of lymphocyte immunoregulatory biomarkers in bone and soft-tissue sarcomas
    Dancsok, Amanda R.
    Setsu, Nokitaka
    Gao, Dongxia
    Blay, Jean-Yves
    Thomas, David
    Maki, Robert G.
    Nielsen, Torsten O.
    Demicco, Elizabeth G.
    MODERN PATHOLOGY, 2019, 32 (12) : 1772 - 1785
  • [44] Immunotherapy: A New (and Old) Approach to Treatment of Soft Tissue and Bone Sarcomas
    Nathenson, Michael J.
    Conley, Anthony P.
    Sausville, Edward
    ONCOLOGIST, 2018, 23 (01) : 71 - 83
  • [45] Fatigue Syndrome in Patients with Bone and Soft Tissue Sarcomas: An Observational Study
    Morri, Mattia
    Boccomino, Riccardo
    Brruku, Eugenio
    Terra, Ausilia Bellina
    Boschi, Rita
    Raucci, Giovanni
    Sabbi, Daniela
    Ibrahim, Toni
    Coluccino, Paola
    SEMINARS IN ONCOLOGY NURSING, 2025, 41 (01)
  • [46] Soft-tissue sarcoma involving bone or neurovascular structures: MR imaging prognostic factors
    Panicek, DM
    Go, SD
    Healey, JH
    Leung, DHY
    Brennan, MF
    Lewis, JJ
    RADIOLOGY, 1997, 205 (03) : 871 - 875
  • [47] Molecular targets in therapy for human soft-tissue and bone sarcomas
    Dejka M. Steinert
    L. Johnetta Blakely
    Jason Salganick
    Jonathan C. Trent
    Current Oncology Reports, 2003, 5 (4) : 295 - 303
  • [48] Early symptoms of bone and soft tissue sarcomas: could they be diagnosed earlier?
    George, A.
    Grimer, R.
    ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND, 2012, 94 (04) : 261 - 266
  • [49] Hypofractionated radiotherapy for non-metastatic bone and soft tissue sarcomas
    Sari, S. Yuce
    Cengiz, M.
    Dauletkazin, A.
    Yazici, G.
    Gultekin, M.
    Hurmuz, P.
    Yildiz, F.
    Zorlu, F.
    Gurkaynak, M.
    Akyol, F.
    Ozyigit, G.
    CANCER RADIOTHERAPIE, 2019, 23 (08): : 853 - 859
  • [50] Endoprosthetic reconstruction for lower extremity soft tissue sarcomas with bone involvement
    Rowell, P. D.
    Ferguson, P. C.
    Tsoi, K. M.
    Nevin, J. L.
    Novak, R.
    Griffin, A. M.
    Wunder, J. S.
    JOURNAL OF SURGICAL ONCOLOGY, 2023, 128 (04) : 660 - 666