Value added: functional MR imaging in management of bone and soft tissue sarcomas
被引:22
作者:
Subhawong, Ty K.
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机构:
Univ Miami, Dept Radiol, Miller Sch Med, Jackson Mem Hosp, Miami, FL USAUniv Miami, Dept Radiol, Miller Sch Med, Jackson Mem Hosp, Miami, FL USA
Subhawong, Ty K.
[1
]
Wilky, Breelyn A.
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机构:
Univ Miami, Div Hematol Oncol, Dept Med, Miller Sch Med,Sylvester Comprehens Canc Ctr, Miami, FL USAUniv Miami, Dept Radiol, Miller Sch Med, Jackson Mem Hosp, Miami, FL USA
Wilky, Breelyn A.
[2
]
机构:
[1] Univ Miami, Dept Radiol, Miller Sch Med, Jackson Mem Hosp, Miami, FL USA
[2] Univ Miami, Div Hematol Oncol, Dept Med, Miller Sch Med,Sylvester Comprehens Canc Ctr, Miami, FL USA
Purpose of review MRI plays a crucial role in the initial diagnosis, treatment planning, and long-term management of bone and soft tissue sarcomas. Technological advances have enabled improvements in both delineation of anatomic detail, and in functional imaging techniques that interrogate tissues at the cellular level. This bears particular relevance in sarcomas as morphological parameters alone do not necessarily correlate with treatment response and prognosis. Here, we describe recent developments in advanced MRI techniques, including chemical-shift MRI, diffusion-weighted imaging (DWI), MR spectroscopy (MRS), and dynamic contrast enhanced (DCE) MRI. Recent findings Chemical-shift MRI allows robust discrimination of marrow infiltrating neoplasms from benign red marrow. DWI reveals tumor cellularity, and aids in distinguishing benign and malignant tumors along with the assessment of treatment response. MRS is technically challenging in the musculoskeletal system, but shows promise as a means to noninvasively assess metabolic aberrations in a variety of sarcomas. DCE is particularly suited to treatment response evaluation, in which traditional size-based assessment criteria may underestimate efficacy in clinical trials. Summary Functional MRI techniques offer novel imaging biomarkers that effectively complement conventional MRI in the assessment of bone and soft tissue sarcomas at all stages of patient care.
机构:
Vancouver Coastal Hlth Res Inst, Dept Pathol & Lab Med, Vancouver, BC, Canada
Univ British Columbia, Vancouver, BC, CanadaVancouver Coastal Hlth Res Inst, Dept Pathol & Lab Med, Vancouver, BC, Canada
Dancsok, Amanda R.
Setsu, Nokitaka
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机构:
Kyushu Univ, Grad Sch Med Sci, Dept Anat Pathol, Fukuoka, Fukuoka 8128582, JapanVancouver Coastal Hlth Res Inst, Dept Pathol & Lab Med, Vancouver, BC, Canada
Setsu, Nokitaka
Gao, Dongxia
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机构:
Vancouver Coastal Hlth Res Inst, Dept Pathol & Lab Med, Vancouver, BC, Canada
Univ British Columbia, Vancouver, BC, CanadaVancouver Coastal Hlth Res Inst, Dept Pathol & Lab Med, Vancouver, BC, Canada
Gao, Dongxia
Blay, Jean-Yves
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Ctr Leon Berard, Dept Med Oncol, Lyon, France
Univ Claude Bernard Lyon, Lyon, FranceVancouver Coastal Hlth Res Inst, Dept Pathol & Lab Med, Vancouver, BC, Canada
Blay, Jean-Yves
Thomas, David
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Garvan Inst Med Res, Kinghorn Canc Ctr, Darlinghurst, NSW, Australia
Garvan Inst Med Res, Canc Div, Darlinghurst, NSW, AustraliaVancouver Coastal Hlth Res Inst, Dept Pathol & Lab Med, Vancouver, BC, Canada
Thomas, David
Maki, Robert G.
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机构:
Northwell Hlth Monter Canc Ctr, New York, NY USA
Cold Spring Harbor Lab, New York, NY USAVancouver Coastal Hlth Res Inst, Dept Pathol & Lab Med, Vancouver, BC, Canada
Maki, Robert G.
Nielsen, Torsten O.
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机构:
Vancouver Coastal Hlth Res Inst, Dept Pathol & Lab Med, Vancouver, BC, Canada
Univ British Columbia, Vancouver, BC, CanadaVancouver Coastal Hlth Res Inst, Dept Pathol & Lab Med, Vancouver, BC, Canada
Nielsen, Torsten O.
Demicco, Elizabeth G.
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机构:
Univ Toronto, Mt Sinai Hosp, Dept Pathol & Lab Med, Toronto, ON, Canada
Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, CanadaVancouver Coastal Hlth Res Inst, Dept Pathol & Lab Med, Vancouver, BC, Canada
机构:
Vancouver Coastal Hlth Res Inst, Dept Pathol & Lab Med, Vancouver, BC, Canada
Univ British Columbia, Vancouver, BC, CanadaVancouver Coastal Hlth Res Inst, Dept Pathol & Lab Med, Vancouver, BC, Canada
Dancsok, Amanda R.
Setsu, Nokitaka
论文数: 0引用数: 0
h-index: 0
机构:
Kyushu Univ, Grad Sch Med Sci, Dept Anat Pathol, Fukuoka, Fukuoka 8128582, JapanVancouver Coastal Hlth Res Inst, Dept Pathol & Lab Med, Vancouver, BC, Canada
Setsu, Nokitaka
Gao, Dongxia
论文数: 0引用数: 0
h-index: 0
机构:
Vancouver Coastal Hlth Res Inst, Dept Pathol & Lab Med, Vancouver, BC, Canada
Univ British Columbia, Vancouver, BC, CanadaVancouver Coastal Hlth Res Inst, Dept Pathol & Lab Med, Vancouver, BC, Canada
Gao, Dongxia
Blay, Jean-Yves
论文数: 0引用数: 0
h-index: 0
机构:
Ctr Leon Berard, Dept Med Oncol, Lyon, France
Univ Claude Bernard Lyon, Lyon, FranceVancouver Coastal Hlth Res Inst, Dept Pathol & Lab Med, Vancouver, BC, Canada
Blay, Jean-Yves
Thomas, David
论文数: 0引用数: 0
h-index: 0
机构:
Garvan Inst Med Res, Kinghorn Canc Ctr, Darlinghurst, NSW, Australia
Garvan Inst Med Res, Canc Div, Darlinghurst, NSW, AustraliaVancouver Coastal Hlth Res Inst, Dept Pathol & Lab Med, Vancouver, BC, Canada
Thomas, David
Maki, Robert G.
论文数: 0引用数: 0
h-index: 0
机构:
Northwell Hlth Monter Canc Ctr, New York, NY USA
Cold Spring Harbor Lab, New York, NY USAVancouver Coastal Hlth Res Inst, Dept Pathol & Lab Med, Vancouver, BC, Canada
Maki, Robert G.
Nielsen, Torsten O.
论文数: 0引用数: 0
h-index: 0
机构:
Vancouver Coastal Hlth Res Inst, Dept Pathol & Lab Med, Vancouver, BC, Canada
Univ British Columbia, Vancouver, BC, CanadaVancouver Coastal Hlth Res Inst, Dept Pathol & Lab Med, Vancouver, BC, Canada
Nielsen, Torsten O.
Demicco, Elizabeth G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Mt Sinai Hosp, Dept Pathol & Lab Med, Toronto, ON, Canada
Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, CanadaVancouver Coastal Hlth Res Inst, Dept Pathol & Lab Med, Vancouver, BC, Canada