Discovering orphans' sweet secret: NR4A receptors and hepatic glucose production
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作者:
Diaz, Mauricio Berriel
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German Canc Res Ctr, Emmy Noether Res Grp, Mol Metab Control A170, D-69120 Heidelberg, GermanyGerman Canc Res Ctr, Emmy Noether Res Grp, Mol Metab Control A170, D-69120 Heidelberg, Germany
Diaz, Mauricio Berriel
[1
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Lemke, Ulrike
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German Canc Res Ctr, Emmy Noether Res Grp, Mol Metab Control A170, D-69120 Heidelberg, GermanyGerman Canc Res Ctr, Emmy Noether Res Grp, Mol Metab Control A170, D-69120 Heidelberg, Germany
Lemke, Ulrike
[1
]
Herzig, Stephan
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German Canc Res Ctr, Emmy Noether Res Grp, Mol Metab Control A170, D-69120 Heidelberg, GermanyGerman Canc Res Ctr, Emmy Noether Res Grp, Mol Metab Control A170, D-69120 Heidelberg, Germany
Herzig, Stephan
[1
]
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[1] German Canc Res Ctr, Emmy Noether Res Grp, Mol Metab Control A170, D-69120 Heidelberg, Germany
Aberrant hepatic gluconeogenesis contributes importantly to hyperglycemia in type II diabetic patients. A study by Pei et al. (2006b) identifies NR4A orphan nuclear receptors as a novel branch of cAMP-dependent regulators of hepatic glucose production under healthy and diabetic conditions.