SNP276G>T polymorphism in the adiponectin gene is associated with metabolic syndrome in patients with Type II diabetes mellitus in Korea

被引：12
|
作者：
Hwang, J-Y [1 ]
Park, J. E. [1 ]
Choi, Y. J. [2 ]
Huh, K. B. [2 ]
Kim, W. Y. [1 ]
机构：
[1] Ewha Womans Univ, Dept Nutr Sci & Food Management, Seoul 120750, South Korea
[2] 21C Diabet & Vasc Res Ctr, Seoul, South Korea
来源：
EUROPEAN JOURNAL OF CLINICAL NUTRITION | 2010年 / 64卷 / 01期
关键词：
SNP276G > T polymorphism; adiponectin gene; metabolic syndrome; type II diabetes mellitus; INSULIN-RESISTANCE; OBESITY;
D O I：
10.1038/ejcn.2009.94
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Few studies have examined an association between SNP276 and the risk of metabolic syndrome (MetS), which accelerates the development of diabetic complications, in patients with type II diabetes mellitus (T2DM). This study examined whether the SNP276G>T polymorphism is associated with risk of MetS in 673 Korean patients with T2DM from an ongoing prospective study. Multiple logistic regression analysis revealed that the OR for MetS was greater in patients with the TT genotype than in those with the GG genotype (OR=2.071; 95% CI=1.088-3.943) after adjustment of the putative risk factors for MetS. After examining the relationship between serum adiponectin and MetS risk for each genotype, only in patients with the GT genotype, serum adiponectin was negatively associated with the risk of MetS (OR=0.287; 95% CI=0.193-0.427). The SNP276G>T polymorphism may have an independent role in the determination of MetS in Korean patients with T2DM. European Journal of Clinical Nutrition (2010) 64, 105-107; doi:10.1038/ejcn.2009.94; published online 19 August 2009
引用
收藏
页码：105 / 107
页数：3
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