The Effect of Cannabinoids on the Brain's Circadian Clock

被引:2
作者
Goycolea, Claudio Acuna [1 ]
机构
[1] Heidelberg Univ, Inst Anat & Cell Biol, Lab Neural Circuits & Behav Chica & Heinz Schalle, Heidelberg, Germany
来源
CANNABINOIDS AND SLEEP: MOLECULAR, FUNCTIONAL AND CLINICAL ASPECTS | 2021年 / 1297卷
关键词
Suprachiasmatic; Cannabinoids; Hypothalamus; Synaptic transmission; Time perception; ENDOGENOUS CANNABINOIDS; SUPRACHIASMATIC NUCLEUS; NEURONS; RAT;
D O I
10.1007/978-3-030-61663-2_10
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The circadian rhythm is without a doubt the main element influencing the way human lead their lives. Emerging evidence indicate that cannabinoids affect these routines by regulating neuronal firing within the suprachiasmatic nucleus, the master circadian pacemaker in the brain. These actions of cannabinoids on the brain's clock may also underlie time-wraps commonly experienced by marijuana users.
引用
收藏
页码:143 / 146
页数:4
相关论文
共 17 条
[1]   Cannabinoids Excite Circadian Clock Neurons [J].
Acuna-Goycolea, Claudio ;
Obrietan, Karl ;
van den Pol, Anthony N. .
JOURNAL OF NEUROSCIENCE, 2010, 30 (30) :10061-10066
[2]   CIRCADIAN-RHYTHM OF FIRING RATE RECORDED FROM SINGLE CELLS IN THE RAT SUPRACHIASMATIC BRAIN SLICE [J].
GREEN, DJ ;
GILLETTE, R .
BRAIN RESEARCH, 1982, 245 (01) :198-200
[3]   REGULARLY FIRING NEURONS IN THE RAT SUPRACHIASMATIC NUCLEUS [J].
GROOS, GA ;
HENDRIKS, J .
EXPERIENTIA, 1979, 35 (12) :1597-1599
[4]   Distribution of type 1 cannabinoid receptor-expressing neurons in the septal-hypothalamic region of the mouse: Colocalization with GABAergic and glutamatergic markers [J].
Hrabovszky, Erik ;
Wittmann, Gabor ;
Kallo, Imre ;
Fuezesi, Tamas ;
Fekete, Csaba ;
Liposits, Zsolt .
JOURNAL OF COMPARATIVE NEUROLOGY, 2012, 520 (05) :1005-1020
[5]   Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells [J].
Kreitzer, AC ;
Regehr, WG .
NEURON, 2001, 29 (03) :717-727
[6]   Dichotomous Organization of the External Globus Pallidus [J].
Mallet, Nicolas ;
Micklem, Benjamin R. ;
Henny, Pablo ;
Brown, Matthew T. ;
Williams, Claire ;
Bolam, J. Paul ;
Nakamura, Kouichi C. ;
Magill, Peter J. .
NEURON, 2012, 74 (06) :1075-1086
[7]   Expression of the cannabinoid receptor CB1 in distinct neuronal subpopulations in the adult mouse forebrain [J].
Marsicano, G ;
Lutz, B .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1999, 11 (12) :4213-4225
[8]   Cb1 cannabinoid receptors are enriched in the perisynaptic annulus and on preterminal segments of hippocampal GABAergic axons [J].
Nyíri, G ;
Cserép, C ;
Szabadits, E ;
Mackie, K ;
Freund, TF .
NEUROSCIENCE, 2005, 136 (03) :811-822
[9]   Endogenous cannabinoids mediate retrograde signals from depolarized postsynaptic neurons to presynaptic terminals [J].
Ohno-Shosaku, T ;
Maejima, T ;
Kano, M .
NEURON, 2001, 29 (03) :729-738
[10]   The molecular logic of endocannabinoid signalling [J].
Piomelli, D .
NATURE REVIEWS NEUROSCIENCE, 2003, 4 (11) :873-884