Synthesis, chemical stability and application of a thiohydroxamic acid linker (THA) for solid-phase organic synthesis

被引：3

作者：

Whitehead, David M. ^{[1
]}

Helliwell, Philip A. ^{[1
]}

McKeown, Stephen C. ^{[2
]}

Routledge, Anne ^{[1
]}

机构：

[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England

[2] GlaxoSmithKline, Harlow CM19 5AW, Essex, England

来源：

REACTIVE & FUNCTIONAL POLYMERS | 2009年 / 69卷 / 12期

基金：

英国工程与自然科学研究理事会;

关键词：

Radical reaction; Solid-phase synthesis; Thiohydroxamic acid; RADICAL CHEMISTRY; DECARBOXYLATIVE REARRANGEMENT; GENERATION; ESTERS; TRACELESS; INVENTION; DESIGN;

D O I：

10.1016/j.reactfunctpolym.2009.09.003

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The synthesis and chemical compatibility of a 'traceless' thiohydroxamic acid (THA) linker is reported. The linker is shown to be stable to visible light and heat. This paper also describes preliminary work in the application of the THA linker to act as a polymer-supported source of radicals. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：884 / 890

页数：7

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