Mapping of cardiac electrical activity by means of a 3D heart-excitation-model

We have developed new methods for localizing and imaging cardiac activation within three-dimensional (31)) myocardium by means of a heart-excitation-model. The site of origin and sequence of myocardial activation are estimated by minimizing multiple objective functions of the measured and the heart-model-generated body surface potential maps (BSPMs). Computer simulation studies have been conducted to evaluate the developed 3D localization and imaging appraoch, using a pacing protocol. A pilot experimental study was also conducted to assess the performance of the localization procedure in localizing the site of origin of ventricular activation. Our promising results suggest that the developed method may become an alternative in mapping cardiac activation.