Effects of chronic chrysin treatment in spontaneously hypertensive rats

被引：66

作者：

Villar, IC ^{[1
]}

Jiménez, R ^{[1
]}

Galisteo, M ^{[1
]}

Garcia-Saura, MF ^{[1
]}

Zarzuelo, A ^{[1
]}

Duarte, J ^{[1
]}

机构：

[1] Univ Granada, Sch Pharm, Dept Pharmacol, Granada 18071, Spain

来源：

PLANTA MEDICA | 2002年 / 68卷 / 09期

关键词：

D O I：

10.1055/s-2002-34400

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The effects of an oral daily dose (20 mg kg(-1)) of the flavonoid chrysin for 6 weeks in spontaneously hypertensive (SHR) and normotensive Wistar Kyoto rats (WKY) were analysed. Chrysin reduces SHR elevated blood pressure, cardiac hypertrophy and functional vascular changes, but is without effect in WKY. These protective effects were associated with a reduced oxidative status due to the antioxidant properties of the drug.

引用

页码：847 / 850

页数：4

共 11 条

[1] Investigation into the sources of superoxide in human blood vessels - Angiotensin II increases superoxide production in human internal mammary arteries [J].

Berry, C ;

Hamilton, CA ;

Brosnan, J ;

Magill, FG ;

Berg, GA ;

McMurray, JJV ;

Dominiczak, AF .

CIRCULATION, 2000, 101 (18) :2206-2212

[2] Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats [J].

Duarte, J ;

Pérez-Palencia, R ;

Vargas, F ;

Ocete, MA ;

Pérez-Vizcaino, F ;

Zarzuelo, A ;

Tamargo, J .

BRITISH JOURNAL OF PHARMACOLOGY, 2001, 133 (01) :117-124

[3] Vasorelaxant effects of the bioflavonoid chrysin in isolated rat aorta [J].

Duarte, J ;

Jiménez, R ;

Villar, IC ;

Pérez-Vizcaíno, F ;

Jiménez, J ;

Tamargo, J .

PLANTA MEDICA, 2001, 67 (06) :567-569

[4]

FROCHLICH E, 1993, NEW ENGL J MED, V327, P998

[5]

Griendling KK, 1997, CIRCULATION, V96, P3264

[6] ROLE OF SUPEROXIDE IN THE DEPRESSED NITRIC-OXIDE PRODUCTION BY THE ENDOTHELIUM OF GENETICALLY HYPERTENSIVE RATS [J].

GRUNFELD, S ;

HAMILTON, CA ;

MESAROS, S ;

MCCLAIN, SW ;

DOMINICZAK, AF ;

BOHR, DF ;

MALINSKI, T .

HYPERTENSION, 1995, 26 (06) :854-857

[7] ENDOTHELIUM-DERIVED CONTRACTING FACTORS IN RESISTANCE ARTERIES OF YOUNG SPONTANEOUSLY HYPERTENSIVE RATS BEFORE DEVELOPMENT OF OVERT HYPERTENSION [J].

JAMESON, M ;

DAI, FX ;

LUSCHER, T ;

SKOPEC, J ;

DIEDERICH, A ;

DIEDERICH, D .

HYPERTENSION, 1993, 21 (03) :280-288

[8] The isoprostanes - Current knowledge and directions for future research [J].

Morrow, JD ;

Roberts, LJ .

BIOCHEMICAL PHARMACOLOGY, 1996, 51 (01) :1-9

[9] Structure-antioxidant activity relationships of flavonoids and phenolic acids [J].

RiceEvans, CA ;

Miller, NJ ;

Paganga, G .

FREE RADICAL BIOLOGY AND MEDICINE, 1996, 20 (07) :933-956

[10] Flavonoids of honey and propolis: Characterization and effects on hepatic drug-metabolizing enzymes and benzo[a]pyrene-DNA binding in rats [J].

Siess, MH ;

LeBon, AM ;

CanivencLavier, MC ;

Amiot, MJ ;

Sabatier, S ;

Aubert, SY ;

Suschetet, M .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1996, 44 (08) :2297-2301

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