Bone and Muscle Endocrine Functions: Unexpected Paradigms of Inter-organ Communication

被引：206

作者：

Karsenty, Gerard ^{[1
]}

Olson, Eric N. ^{[2
,3
]}

机构：

[1] Columbia Univ, Dept Genet & Dev, Coll Phys & Surg, New York, NY 10032 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA

[3] Univ Texas SW Med Ctr Dallas, Hamon Ctr Regenerat Sci & Med, Dallas, TX 75390 USA

来源：

CELL | 2016年 / 164卷 / 06期

关键词：

SYMPATHETIC-NERVOUS-SYSTEM; NATRIURETIC PEPTIDE; SKELETAL-MUSCLE; ENERGY-METABOLISM; LEPTIN REGULATION; DEFICIENT MICE; BROWN FAT; TGF-BETA; OSTEOCALCIN; MASS;

D O I：

10.1016/j.cell.2016.02.043

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Most physiological functions originate with the communication between organs. Mouse genetics has revived this holistic view of physiology through the identification of inter-organ communications that are unanticipated, functionally important, and would have been difficult to uncover otherwise. This Review highlights this point by showing how two tissues usually not seen as endocrine ones, bone and striated muscles, influence several physiological processes in a significant manner.

引用

页码：1248 / 1256

页数：9

共 59 条

[1] Muscle as a "Mediator" of Systemic Metabolism [J].

Baskin, Kedryn K. ;

Winders, Benjamin R. ;

Olson, Eric N. .

CELL METABOLISM, 2015, 21 (02) :237-248

[2] MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver [J].

Baskin, Kedryn K. ;

Grueter, Chad E. ;

Kusminski, Christine M. ;

Holland, William L. ;

Bookout, Angie L. ;

Satapati, Santosh ;

Kong, Y. Megan ;

Burgess, Shawn C. ;

Malloy, Craig R. ;

Scherer, Philipp E. ;

Newgard, Christopher B. ;

Bassel-Duby, Rhonda ;

Olson, Eric N. .

EMBO MOLECULAR MEDICINE, 2014, 6 (12) :1610-1621

[3] The heart-liver metabolic axis: defective communication exacerbates disease [J].

Baskin, Kedryn K. ;

Bookout, Angie L. ;

Olson, Eric N. .

EMBO MOLECULAR MEDICINE, 2014, 6 (04) :436-438

[4] Exercise as an anti-inflammatory therapy for rheumatic diseases-myokine regulation [J].

Benatti, Fabiana B. ;

Pedersen, Bente K. .

NATURE REVIEWS RHEUMATOLOGY, 2015, 11 (02) :86-97

[5] Atrial Natriuretic Peptide and Adiponectin Interactions in Man [J].

Birkenfeld, Andreas L. ;

Boschmann, Michael ;

Engeli, Stefan ;

Moro, Cedric ;

Arafat, Ayman M. ;

Luft, Friedrich C. ;

Jordan, Jens .

PLOS ONE, 2012, 7 (08)

[6] Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes [J].

Bordicchia, Marica ;

Liu, Dianxin ;

Amri, Ez-Zoubir ;

Ailhaud, Gerard ;

Dessi-Fulgheri, Paolo ;

Zhang, Chaoying ;

Takahashi, Nobuyuki ;

Sarzani, Riccardo ;

Collins, Sheila .

JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (03) :1022-1036

[7] Myostatin - The Holy Grail for Muscle, Bone, and Fat? [J].

Buehring, B. ;

Binkley, N. .

CURRENT OSTEOPOROSIS REPORTS, 2013, 11 (04) :407-414

[8] Mediator-dependent nuclear receptor function [J].

Chen, Wei ;

Roeder, Robert G. .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2011, 22 (07) :749-758

[9] A heart-adipose tissue connection in the regulation of energy metabolism [J].

Collins, Sheila .

NATURE REVIEWS ENDOCRINOLOGY, 2014, 10 (03) :157-163

[10] Heart hormones fueling a fire in fat [J].

Collins, Sheila ;

Bordicchia, Marica .

ADIPOCYTE, 2013, 2 (02) :104-108

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