DNA interstrand cross-link repair in Saccharomyces cerevisiae

被引:63
作者
Lehoczky, Peter
McHugh, Peter J.
Chovanec, Miroslav
机构
[1] Canc Res Inst, Dept Mol Genet, Bratislava 83391, Slovakia
[2] Univ Oxford, John Radcliffe Hosp, Canc Res UK Labs, Weatherall Inst Mol Med, Oxford OX3 9DU, England
关键词
anticancer drugs; DNA interstrand cross-links; Saccharomyces cerevisiae; nucleotide excision repair; homologous recombination repair; translesion polymerases;
D O I
10.1111/j.1574-6976.2006.00046.x
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
DNA interstrand cross-links (ICL) present a formidable challenge to the cellular DNA repair apparatus. For Escherichia coli, a pathway which combines nucleotide excision repair (NER) and homologous recombination repair (HRR) to eliminate ICL has been characterized in detail, both genetically and biochemically. Mechanisms of ICL repair in eukaryotes have proved more difficult to define, primarily as a result of the fact that several pathways appear compete for ICL repair intermediates, and also because these competing activities are regulated in the cell cycle. The budding yeast Saccharomyces cerevisiae has proven a powerful tool for dissecting ICL repair. Important roles for NER, HRR and postreplication/translesion synthesis pathways have all been identified. Here we review, with reference to similarities and differences in higher eukaryotes, what has been discovered to date concerning ICL repair in this simple eukaryote.
引用
收藏
页码:109 / 133
页数:25
相关论文
共 251 条
[1]  
ABE H, 1994, ANTICANCER RES, V14, P1807
[2]   DNA replication is required to elicit cellular responses to psoralen-induced DNA interstrand cross-links [J].
Akkari, YMN ;
Bateman, RL ;
Reifsteck, CA ;
Olson, SB ;
Grompe, M .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (21) :8283-8289
[3]   Nucleotide excision repair genes as determinants of cellular sensitivity to cyclophosphamide analogs [J].
Andersson, BS ;
Sadeghi, T ;
Siciliano, MJ ;
Legerski, R ;
Murray, D .
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 1996, 38 (05) :406-416
[4]   Conserved domains in DNA repair proteins and evolution of repair systems [J].
Aravind, L ;
Walker, DR ;
Koonin, EV .
NUCLEIC ACIDS RESEARCH, 1999, 27 (05) :1223-1242
[5]   Sister chromatid-based DNA repair is mediated by RAD54, not by DMC1 or TID1 [J].
Arbel, A ;
Zenvirth, D ;
Simchen, G .
EMBO JOURNAL, 1999, 18 (09) :2648-2658
[6]   CLONING, DISRUPTION AND SEQUENCE OF THE GENE ENCODING YEAST C-5 STEROL DESATURASE [J].
ARTHINGTON, BA ;
BENNETT, LG ;
SKATRUD, PL ;
GUYNN, CJ ;
BARBUCH, RJ ;
ULBRIGHT, CE ;
BARD, M .
GENE, 1991, 102 (01) :39-44
[7]   NEW ASPECTS OF THE REPAIR AND GENOTOXICITY OF PSORALEN PHOTOINDUCED LESIONS IN DNA [J].
AVERBECK, D ;
DARDALHON, M ;
MAGANASCHWENCKE, N ;
MEIRA, LB ;
MENIEL, V ;
BOITEUX, S ;
SAGE, E .
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY, 1992, 14 (1-2) :47-63
[8]  
Averbeck D, 1998, PHOTOCHEM PHOTOBIOL, V68, P289, DOI 10.1562/0031-8655(1998)068<0289:DPRGIA>2.3.CO
[9]  
2
[10]  
Bacolod MD, 2002, MOL CANCER THER, V1, P727