Effect of chirality of L/D-proline and prochiral glycine as the linker amino acid in five-atom linked thymidinyl-(α-aminoacid)-thymidine dimers

被引：18
作者：
Bagmare, Seema [1 ]
D'Costa, Moneesha [1 ]
Kumar, Vaijayanti A. [1 ]
机构：
[1] Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India
来源：
CHEMICAL COMMUNICATIONS | 2009年 / 43期
基金：
英国惠康基金;
关键词：
PEPTIDE NUCLEIC-ACIDS; PNA ANALOGS; SEQUENCE; OLIGONUCLEOTIDES; DNA; CONFORMATION; SELECTIVITY; SIRNA; RING;
D O I：
10.1039/b913546d
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The chirality of the amide linker in dimer blocks was found to have a profound effect on the orientation of base stacking interactions as studied by CD and NMR spectroscopy.
引用
收藏
页码：6646 / 6648
页数：3
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