Effect of chirality of L/D-proline and prochiral glycine as the linker amino acid in five-atom linked thymidinyl-(α-aminoacid)-thymidine dimers

被引：18

作者：

Bagmare, Seema ^{[1
]}

D'Costa, Moneesha ^{[1
]}

Kumar, Vaijayanti A. ^{[1
]}

机构：

[1] Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 43期

基金：

英国惠康基金;

关键词：

PEPTIDE NUCLEIC-ACIDS; PNA ANALOGS; SEQUENCE; OLIGONUCLEOTIDES; DNA; CONFORMATION; SELECTIVITY; SIRNA; RING;

D O I：

10.1039/b913546d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The chirality of the amide linker in dimer blocks was found to have a profound effect on the orientation of base stacking interactions as studied by CD and NMR spectroscopy.

引用

页码：6646 / 6648

页数：3

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