Congestive heart failure and toxic digoxin levels: Role of cholestyramine

被引：0
|
作者：
Roberge, RJ
Sorensen, T
机构：
[1] Western Penn Hosp, Dept Emergency Med, Pittsburgh, PA 15224 USA
[2] Univ Pittsburgh, Sch Med, Affliated Residency Emergency Med, Pittsburgh, PA USA
来源：
VETERINARY AND HUMAN TOXICOLOGY | 2000年 / 42卷 / 03期
关键词：
D O I：
暂无
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
We report 2 patients with congestive heart failure and concomitant toxic serum digoxin levels in whom cholestyramine administration increased clearance of digoxin and decreased serum digoxin elimination half-lives. Cholestyramine's gastrointestinal binding of enterohepatically-recycled and enterally-secreted digoxin enhanced elimination, allowing a more rapid return to therapeutic drug levels.
引用
收藏
页码：172 / 173
页数：2
相关论文
共 50 条
  • [31] SOME EFFECTS OF DIGOXIN ON THE HEART AND CIRCULATION IN MAN - DIGOXIN IN ENLARGED HEARTS NOT IN CLINICAL CONGESTIVE FAILURE
    HARVEY, RM
    FERRER, MI
    CATHCART, RT
    ALEXANDER, JK
    CIRCULATION, 1951, 4 (03) : 366 - 377
  • [32] THE EFFECT OF LISINOPRIL ON DIGOXIN PHARMACOKINETICS IN PATIENTS WITH CONGESTIVE HEART-FAILURE
    VANDENBURG, MJ
    KELLY, JG
    WISEMAN, HT
    MANNERING, D
    LONG, C
    GLOVER, DR
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1988, 25 (05) : P656 - P657
  • [33] Pharmacokinetics of digoxin in children with congestive heart failure aggravated by other diseases
    Lares-Asseff, I
    Juárez-Olguín, H
    Flores-Pérez, J
    Bobadilla-Chávez, J
    REVISTA DE INVESTIGACION CLINICA-CLINICAL AND TRANSLATIONAL INVESTIGATION, 2004, 56 (01): : 32 - 37
  • [34] A COMPARATIVE TRIAL OF DIGOXIN AND DIGITOXIN IN THE TREATMENT OF CONGESTIVE HEART-FAILURE
    BUSSEY, HI
    HAWKINS, DW
    GASPARD, JJ
    WALSH, RA
    PHARMACOTHERAPY, 1988, 8 (04): : 235 - 240
  • [35] THE ROLE OF ALDOSTERONE IN CONGESTIVE HEART FAILURE
    GORDON, ES
    JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 1955, 46 (05): : 820 - 821
  • [36] Role of endothelins in congestive heart failure
    Moe, GW
    Rouleau, JL
    Nguyen, QT
    Cernacek, P
    Stewart, DJ
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 2003, 81 (06) : 588 - 597
  • [37] DECREASED RENAL CLEARANCE OF DIGOXIN IN CHRONIC CONGESTIVE HEART-FAILURE
    NAAFS, MAB
    VANDERHOEK, C
    VANDUIN, S
    KOOREVAAR, G
    SCHOPMAN, W
    SILBERBUSCH, J
    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1985, 28 (03) : 249 - 252
  • [38] Digoxin reduces cardiac sympathetic activity in severe congestive heart failure
    Newton, GE
    Tong, JH
    Schofield, AM
    Baines, AD
    Floras, JS
    Parker, JD
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1996, 28 (01) : 155 - 161
  • [39] Digoxin may reduce the mortality rates in patients with congestive heart failure
    Wang, LX
    Song, SK
    MEDICAL HYPOTHESES, 2005, 64 (01) : 124 - 126
  • [40] LACK OF EFFECT OF CAPTOPRIL ON SERUM DIGOXIN IN CONGESTIVE HEART-FAILURE
    MAGELLI, C
    BASSEIN, L
    RIBANI, MA
    LIBERATORE, S
    AMBROSIONI, E
    MAGNANI, B
    EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1989, 36 (01) : 99 - 100
12345