Congestive heart failure and toxic digoxin levels: Role of cholestyramine

被引：0
|
作者：
Roberge, RJ
Sorensen, T
机构：
[1] Western Penn Hosp, Dept Emergency Med, Pittsburgh, PA 15224 USA
[2] Univ Pittsburgh, Sch Med, Affliated Residency Emergency Med, Pittsburgh, PA USA
来源：
VETERINARY AND HUMAN TOXICOLOGY | 2000年 / 42卷 / 03期
关键词：
D O I：
暂无
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
We report 2 patients with congestive heart failure and concomitant toxic serum digoxin levels in whom cholestyramine administration increased clearance of digoxin and decreased serum digoxin elimination half-lives. Cholestyramine's gastrointestinal binding of enterohepatically-recycled and enterally-secreted digoxin enhanced elimination, allowing a more rapid return to therapeutic drug levels.
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页码：172 / 173
页数：2
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