Mammalian DNA Polymerase Kappa Activity and Specificity

被引：24
作者：
Stern, Hannah R. [1 ]
Sefcikova, Jana [1 ]
Chaparro, Victoria E. [1 ]
Beuning, Penny J. [1 ]
机构：
[1] Northeastern Univ, Dept Chem & Chem Biol, Boston, MA 02115 USA
来源：
MOLECULES | 2019年 / 24卷 / 15期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
Y-family; DNA replication; DNA damage; translesion DNA synthesis; primer extension; chemotherapy resistance; INTERSTRAND CROSS-LINKS; ERROR-FREE REPLICATION; Y-FAMILY POLYMERASES; IN-VIVO EVIDENCE; TRANSLESION SYNTHESIS; POL-KAPPA; LESION-BYPASS; DIOL EPOXIDE; CONFORMATIONAL TRANSITIONS; QUANTITATIVE-ANALYSIS;
D O I：
10.3390/molecules24152805
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
DNA polymerase (pol) kappa is a Y-family translesion DNA polymerase conserved throughout all domains of life. Pol kappa is special6 ized for the ability to copy DNA containing minor groove DNA adducts, especially N-2-dG adducts, as well as to extend primer termini containing DNA damage or mismatched base pairs. Pol kappa generally cannot copy DNA containing major groove modifications or UV-induced photoproducts. Pol kappa can also copy structured or non-B-form DNA, such as microsatellite DNA, common fragile sites, and DNA containing G quadruplexes. Thus, pol kappa has roles both in maintaining and compromising genomic integrity. The expression of pol kappa is altered in several different cancer types, which can lead to genome instability. In addition, many cancer-associated single-nucleotide polymorphisms have been reported in the POLK gene, some of which are associated with poor survival and altered chemotherapy response. Because of this, identifying inhibitors of pol kappa is an active area of research. This review will address these activities of pol kappa, with a focus on lesion bypass and cellular mutagenesis.
引用
收藏
页数：20
相关论文
共 154 条
  • [21] Preferential misincorporation of purine nucleotides by human DNA polymerase η opposite benzo[a]pyrene 7,8-diol 9,10-epoxide deoxyguanosine adducts[J]. Chiapperino, D;Kroth, H;Kramarczuk, IH;Sayer, JM;Masutani, C;Hanaoka, F;Jerina, DM;Cheh, AM. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002(14)
  • [22] Translesion synthesis across O6-alkylguanine DNA adducts by recombinant human DNA polymerases[J]. Choi, Jeong-Yun;Chowdhury, Goutam;Zang, Hong;Angel, Karen C.;Vu, Choua C.;Peterson, Lisa A.;Guengerich, F. Peter. JOURNAL OF BIOLOGICAL CHEMISTRY, 2006(50)
  • [23] Translesion synthesis across 1,N2-ethenoguanine by human DNA polymerases[J]. Choi, Jeong-Yun;Zang, Hong;Angel, Karen C.;Kozekov, Ivan D.;Goodenough, Angela K.;Rizzo, Carmelo J.;Guengerich, F. Peter. CHEMICAL RESEARCH IN TOXICOLOGY, 2006(06)
  • [24] Translesion synthesis across bulky N2-alkyl guanine DNA adducts by human DNA polymerase κ[J]. Choi, Jeong-Yun;Angel, Karen C.;Guengerich, F. Peter. JOURNAL OF BIOLOGICAL CHEMISTRY, 2006(30)
  • [25] Translesion Synthesis across Abasic Lesions by Human B-Family and Y-Family DNA Polymerases α, δ, η, I, K, and REV1[J]. Choi, Jeong-Yun;Lim, Seonhee;Kim, Eun-Jin;Jo, Ara;Guengerich, F. Peter. JOURNAL OF MOLECULAR BIOLOGY, 2010(01)
  • [26] Analysis of the effect of bulk at N2-alkylguanine DNA adducts on catalytic efficiency and fidelity of the processive DNA polymerases bacteriophage T7 exonuclease- and HIV-1 reverse transcriptase[J]. Choi, JY;Guengerich, FP. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004(18)
  • [27] Association Between Single Nucleotide Polymorphisms in DNA Polymerase Kappa Gene and Breast Cancer Risk in Chinese Han Population A STROBE-Compliant Observational Study[J]. Dai, Zhi-Jun;Liu, Xing-Han;Ma, Yun-Feng;Kang, Hua-Feng;Jin, Tian-Bo;Dai, Zhi-Ming;Guan, Hai-Tao;Wang, Meng;Liu, Kang;Dai, Cong;Yang, Xue-Wen;Wang, Xi-Jing. MEDICINE, 2016(02)
  • [28] Mutagenic potential of benzo[a] pyrene-derived DNA adducts positioned in codon 273 of the human P53 gene[J]. Dong, H;Bonala, RR;Suzuki, N;Johnson, F;Grollman, AP;Shibutani, S. BIOCHEMISTRY, 2004(50)
  • [29] A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases[J]. Dorjsuren, Dorjbal;Wilson, David M., III;Beard, William A.;McDonald, John P.;Austin, Christopher P.;Woodgate, Roger;Wilson, Samuel H.;Simeonov, Anton. NUCLEIC ACIDS RESEARCH, 2009(19)
  • [30] Repair and translesion synthesis of O6-alkylguanine DNA lesions in human cells[J]. Du, Hua;Wang, Pengcheng;Li, Lin;Wang, Yinsheng. JOURNAL OF BIOLOGICAL CHEMISTRY, 2019(29)
12345678910