Preeclampsia: Pathophysiology and management

被引：84
作者：
Nirupama, R. [1 ]
Divyashree, S. [2 ]
Janhavi, P. [2 ]
Muthukumar, Sp [2 ]
Ravindra, Pv [2 ]
机构：
[1] Penn State Coll Med, Dept Cellular & Mol Physiol, Hershey, PA USA
[2] CSIR CFTRI, Dept Biochem, Mysuru 570020, India
来源：
JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION | 2021年 / 50卷 / 02期
关键词：
Preeclampsia; Hypertension; Pregnancy complication; Placenta; Angiogenic-antiangiogenic factors; ANTI-ANGIOGENIC FACTORS; PLACENTAL GROWTH-FACTOR; ACTIVATE ANGIOTENSIN RECEPTORS; EARLY-ONSET PREECLAMPSIA; ELEVATED LIVER-ENZYMES; TYROSINE KINASE-1; AGONISTIC ANTIBODIES; MATERNAL AUTOANTIBODIES; CORTICOSTEROID-THERAPY; INTRAVENOUS LABETALOL;
D O I：
10.1016/j.jogoh.2020.101975
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Preeclampsia is a pregnancy-related multisystem disorder, frequently encountered pregnancy-related medical complications next to gestational diabetes mellitus. It is the onset of hypertension during pregnancy. The preeclampsia can be of two types, placental or maternal preeclampsia. Among these two types former, i.e., placental preeclampsia is more severe than the latter. According to the recent survey by National Health Portal of India, the incidence of preeclampsia is about 8-10 % among pregnant women. Though our understanding of preeclampsia has improved in recent years, the development and interpretation of the clinical tests remain difficult for preeclampsia. Hence, we have made an attempt to understand the pathophysiology, associated conditions/consequences, treatment and management/prevention of the condition in this review. (C) 2020 Published by Elsevier Masson SAS.
引用
收藏
页数：7
相关论文
共 85 条
[1]   Low urinary placental growth factor is a marker of pre-eclampsia [J].
Aggarwal, PK ;
Jain, V ;
Sakhuja, V ;
Karumanchi, SA ;
Jha, V .
KIDNEY INTERNATIONAL, 2006, 69 (03) :621-624
[2]   Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia [J].
Ahmad, S ;
Ahmed, A .
CIRCULATION RESEARCH, 2004, 95 (09) :884-891
[3]   New insights into the etiology of preeclampsia: identification of key elusive factors for the vascular complications [J].
Ahmed, Asif .
THROMBOSIS RESEARCH, 2011, 127 :S72-S75
[4]   Corticosteroid therapy for prevention of respiratory distress syndrome in severe preeclampsia [J].
Amorim, MMR ;
Santos, LC ;
Faúndes, A .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1999, 180 (05) :1283-1288
[5]   Renal angiotensin-II receptors expression changes in a model of preeclampsia [J].
Anguiano-Robledo, Liliana ;
Reyes-Melchor, Pedro A. ;
Bobadilla-Lugo, Rosa A. ;
Perez-Alvarez, Victor M. ;
Lopez-Sanchez, Pedro .
HYPERTENSION IN PREGNANCY, 2007, 26 (02) :151-161
[6]   REGIONAL FLOW-PRESSURE RELATIONSHIP IN RESPONSE TO ANGIOTENSIN IN INTACT DOG AND SHEEP [J].
ASSALI, NS ;
WESTERSTEN, A .
CIRCULATION RESEARCH, 1961, 9 (01) :189-&
[7]   Vitamin D and Inflammatory Cytokines in Healthy and Preeclamptic Pregnancies [J].
Barrera, David ;
Diaz, Lorenza ;
Noyola-Martinez, Nancy ;
Halhali, Ali .
NUTRIENTS, 2015, 7 (08) :6465-6490
[8]   The endogenous anti-angiogenic family of splice variants of VEGF, VEGFxxxb, are down-regulated in pre-eclamptic placentae at term [J].
Bates, DO ;
MacMillan, PP ;
Manjaly, JG ;
Qiu, Y ;
Hudson, SJ ;
Bevan, HS ;
Hunter, AJ ;
Soothill, PW ;
Read, M ;
Donaldson, LF ;
Harper, SJ .
CLINICAL SCIENCE, 2006, 110 (05) :575-585
[9]   Maternal autoantibodies from preeclamptic patients activate angiotensin receptors on human mesangial cells and induce interleukin-6 and plasminogen activator inhibitor-1 secretion [J].
Bobst, SM ;
Day, MC ;
Gilstrap, LC ;
Xia, Y ;
Kellems, RE .
AMERICAN JOURNAL OF HYPERTENSION, 2005, 18 (03) :330-336
[10]   Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia [J].
Buhimschi, CS ;
Norwitz, ER ;
Funai, E ;
Richman, S ;
Guller, S ;
Lockwood, CJ ;
Buhimschi, IA .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2005, 192 (03) :734-741
123456789