A1C but Not Serum Glycated Albumin Is Elevated Because of Iron Deficiency in Late Pregnancy in Diabetic Women

被引：105

作者：

Hashimoto, Kunihiko ^{[1
]}

Osugi, Tomoaki ^{[1
]}

Noguchi, Sanai ^{[1
]}

Morimoto, Yasuhiko ^{[1
]}

Wasada, Kenshi ^{[2
]}

Imai, Shiro ^{[2
]}

Waguri, Masako ^{[3
,4
]}

Toyoda, Rieko ^{[4
]}

Fujita, Tomio ^{[5
]}

Kasayama, Soji ^{[6
]}

Koga, Masafumi

机构：

[1] Aizenbashi Hosp, Dept Internal Med, Osaka, Japan

[2] Aizenbashi Hosp, Dept Gynecol & Obstet, Osaka, Japan

[3] Osaka Med Ctr, Dept Maternal Med, Osaka, Japan

[4] Res Inst Maternal & Child Hlth, Osaka, Japan

[5] Fujita Clin, Osaka, Japan

[6] Nissay Hosp, Dept Med, Osaka, Japan

来源：

DIABETES CARE | 2010年 / 33卷 / 03期

关键词：

HEMOGLOBIN;

D O I：

10.2337/dc09-1954

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE - We have already reported that A1C is elevated because of iron deficiency in late pregnancy among nondiabetic pregnant women. This report examined whether the same phenomenon is observed in pregnant women with diabetes. RESEARCH DESIGN AND METHODS - This longitudinal study was conducted in 17 pregnant women with diabetes (20-35 weeks of pregnancy). A1C, serum glycated albumin, erythrocyte indexes, and iron metabolism indexes were measured. RESULTS - A1C levels were significantly increased in late pregnancy, whereas serum glycated albumin showed no significant changes. Glycated albumin/A1C ratio, mean corpuscular hemoglobin, serum transferrin saturation, and serum ferritin were significantly decreased in late pregnancy. Serum transferrin saturation showed a significant positive correlation with glycated albumin/A1C ratio. CONCLUSIONS - A1C levels, but riot serum glycated albumin levels, are elevated in late pregnancy because of iron deficiency in diabetic women. Serum glycated albumin may offer an adequate marker for glycemic control during pregnancy.

引用

页码：509 / 511

页数：3

共 15 条

[1] SERUM GLYCATED ALBUMIN CONCENTRATIONS DURING PREGNANCY [J].