Systems Biology of Cancer Metastasis

被引：338

作者：

Suhail, Yasir ^{[1
,2
]}

Cain, Margo P. ^{[3
]}

Vanaja, Kiran ^{[2
]}

Kurywchak, Paul A. ^{[3
]}

Levchenko, Andre ^{[2
]}

Kalluri, Raghu ^{[3
]}

Kshitiz ^{[1
,2
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Dept Biomed Engn, Farmington, CT 06032 USA

[2] Yale Univ, Canc Syst Biol Yale CaSB Yale, New Haven, CT 06520 USA

[3] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA

来源：

CELL SYSTEMS | 2019年 / 9卷 / 02期

关键词：

TO-MESENCHYMAL TRANSITION; TUMOR-CELL INTRAVASATION; BREAST-CANCER; STEM-CELLS; GENE-EXPRESSION; LUNG METASTASIS; CRISPR SCREEN; MODEL; TISSUE; DNA;

D O I：

10.1016/j.cels.2019.07.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series of concurrent, partially overlapping processes, as successfully metastasizing cells assume new phenotypes while jettisoning older behaviors. The lack of a systemic understanding of this complex phenomenon has limited progress in developing treatments for metastatic disease. Because metastasis has traditionally been investigated in distinct physiological compartments, the integration of these complex and interlinked aspects remains a challenge for both systems-level experimental and computational modeling of metastasis. Here, we present some of the current perspectives on the complexity of cancer metastasis, the multiscale nature of its progression, and a systems-level view of the processes underlying the invasive spread of cancer cells. We also highlight the gaps in our current understanding of cancer metastasis as well as insights emerging from interdisciplinary systems biology approaches to understand this complex phenomenon.

引用

页码：109 / 127

页数：19

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