E-cadherin: A potential biomarker of colorectal cancer prognosis (Review)

被引：69

作者：

Christou, Niki ^{[1
,2
]}

Perraud, Aurelie ^{[1
,2
]}

Blondy, Sabrina ^{[1
]}

Jauberteau, Marie-Odile ^{[1
]}

Battu, Serge ^{[1
,2
]}

Mathonnet, Muriel ^{[1
,2
]}

机构：

[1] Univ Limoges, GEIST Inst, Fac Med, Cellular Homeostasis & Pathol, 2 Rue Dr Marcland, F-87025 Limoges, France

[2] Univ Hosp Limoges, Gen Endocrine & Digest Surg Dept, F-87042 Limoges, France

来源：

ONCOLOGY LETTERS | 2017年 / 13卷 / 06期

关键词：

colorectal cancer; biomarkers; E-cadherin protein; EPITHELIAL-MESENCHYMAL TRANSITION; CIRCULATING TUMOR-CELLS; COLON-CARCINOMA CELLS; CLINICAL-SIGNIFICANCE; ADHESION MOLECULES; STRUCTURAL BASIS; METASTASIS; EXPRESSION; INVASION; SERUM;

D O I：

10.3892/ol.2017.6063

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer (CRC) is a common and lethal disease. It is the third most common type of cancer in the world, behind lung and breast cancer, with almost 1.4 million new cases diagnosed in 2012. The risk of developing CRC is influenced by environmental and genetic factors. Adenocarcinomas comprise the vast majority (98%) of CRCs. A patient's likelihood of survival is associated with the tumor stage at the time of diagnosis. With regular screening, CRC can be identified early, when treatment is the most effective. However, CRC is typically asymptomatic until the advanced stages. The combination of the absence of symptoms and current screening methodology results in a significant number of patients being diagnosed in advanced stages. The purpose of the present review is to discuss and summarize the biomarkers linked to CRC progression, particularly the controversial E-cadherin, which is a calcium-dependent cell-cell adhesion molecule involved in the mesenchymal-epithelial transition.

引用

页码：4571 / 4576

页数：6

共 53 条

[41]

2-2

[42] Epigenetic versus genetic alterations in the inactivation of E-cadherin [J].