An efficient synthesis of isoindolo[2,1-a]quinoline derivatives via imino Diels-Alder and intramolecular Diels-Alder reactions with furan

被引：32
作者：
Kouznetsov, Vladimir V.
Cruz, Uriel Mora
Zubkov, Fedor I.
Nikitina, Eugenia V.
机构：
[1] Univ Ind Santander, Escuela Quim, CIBIMOL, Lab Quim Organ & Biomol, Bucaramanga, Colombia
[2] Russian Peoples Friendship Univ, Dept Organ Chem, Moscow 117198, Russia
来源：
SYNTHESIS-STUTTGART | 2007年 / 03期
关键词：
Povarov reaction; quinolines; furans; intramolecular Diels-Alder reaction; isoindolo[2,1-a]quinolines;
D O I：
10.1055/s-2007-965875
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The straightforward synthesis of new isoindolo[2,1a]quinoline derivatives from 2,4-di substituted 1,2,3,4-tetrahydroquinolines bearing a furan fragment via the intramolecular Diels-Alder reaction is reported. The synthesis of key precursors was realized with excellent levels of diastereoselectivity either by Povarov reaction or by a multicomponent condensation approach.
引用
收藏
页码：375 / 384
页数：10
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