The Clinical Value of Myocardial Blood Flow Measurement

被引：153
作者：
Camici, Paolo G.
Rimoldi, Ornella E.
机构：
[1] Univ London Imperial Coll Sci Technol & Med, MRC, Ctr Clin Sci, London, England
[2] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England
来源：
JOURNAL OF NUCLEAR MEDICINE | 2009年 / 50卷 / 07期
基金：
英国医学研究理事会;
关键词：
noninvasive measurement; cardiovascular disease; myocardial blood flow; CORONARY-ARTERY-DISEASE; POSITRON-EMISSION-TOMOGRAPHY; CARDIOVASCULAR MAGNETIC-RESONANCE; PET-MEASURED HETEROGENEITY; 1ST-PASS MR PERFUSION; HYPERTROPHIC CARDIOMYOPATHY; MICROVASCULAR DYSFUNCTION; ADENOSINE STRESS; PHARMACOLOGICAL STRESS; VASODILATOR RESERVE;
D O I：
10.2967/jnumed.108.054478
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
PET provides robust and reproducible measurements of regional myocardial blood flow in milliliters per minute per gram of tissue, providing unique pathophysiologic and diagnostic information on the function of the coronary macro- and microcirculation. There is compelling evidence to suggest that in many instances abnormalities of global myocardial perfusion are demonstrated in individuals with either coronary risk factors for coronary artery disease or different myocardial diseases in the absence of angio-graphically demonstrable stenosis of the epicardial coronary arteries. In this context, measurement of myocardial blood flow gives unique diagnostic information regarding the function of the coronary microcirculation and provides a quantitative surrogate endpoint against which the efficacy of treatments can be established.
引用
收藏
页码：1076 / 1087
页数：12
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