A platform for experimental precision medicine: The extended BXD mouse family

被引：89

作者：

Ashbrook, David G. ^{[1
]}

Arends, Danny ^{[2
]}

Prins, Pjotr ^{[1
]}

Mulligan, Megan K. ^{[1
]}

Roy, Suheeta ^{[1
]}

Williams, Evan G. ^{[3
]}

Lutz, Cathleen M. ^{[4
]}

Valenzuela, Alicia ^{[4
]}

Bohl, Casey J. ^{[1
]}

Ingels, Jesse F. ^{[1
]}

McCarty, Melinda S. ^{[1
]}

Centeno, Arthur G. ^{[1
]}

Hager, Reinmar ^{[5
]}

Auwerx, Johan ^{[6
]}

Lu, Lu ^{[1
]}

Williams, Robert W. ^{[1
]}

机构：

[1] Univ Tennessee, Hlth Sci Ctr, Dept Genet Genom & Informat, Memphis, TN 38163 USA

[2] Humboldt Univ, Albrecht Daniel Thaer Inst, Lebenswissenschaftl Fak, Invalidenstr 42, D-10115 Berlin, Germany

[3] Univ Luxembourg, Luxembourg Ctr Syst Biomed, L-4365 Esch Sur Alzette, Luxembourg

[4] Jackson Lab, Mouse Repository & Rare & Orphan Dis Ctr, 600 Main St, Bar Harbor, ME 04609 USA

[5] Univ Manchester, Manchester Acad Hlth Sci Ctr, Div Evolut & Genom Sci, Fac Biol Med & Hlth, Oxford Rd, Manchester M13 9PL, Lancs, England

[6] Ecole Polytech Fed Lausanne, Lab Integrat Syst Physiol, CH-1015 Lausanne, Switzerland

来源：

CELL SYSTEMS | 2021年 / 12卷 / 03期

关键词：

QUANTITATIVE-TRAIT-LOCI; RECOMBINANT INBRED STRAINS; SYSTEMS GENETICS; COLLABORATIVE CROSS; COMPLEX TRAITS; MICE; DISSECTION; ETHANOL; IDENTIFICATION; RESOLUTION;

D O I：

10.1016/j.cels.2020.12.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The challenge of precision medicine is to model complex interactions among DNA variants, phenotypes, development, environments, and treatments. We address this challenge by expanding the BXD family of mice to 140 fully isogenic strains, creating a uniquely powerful model for precision medicine. This family segregates for 6 million common DNA variants-a level that exceeds many human populations. Because each member can be replicated, heritable traits can be mapped with high power and precision. Current BXD phenomes are unsurpassed in coverage and include much omics data and thousands of quantitative traits. BXDs can be extended by a single-generation cross to as many as 19,460 isogenic F1 progeny, and this extended BXD family is an effective platform for testing causal modeling and for predictive validation. BXDs are a unique core resource for the field of experimental precision medicine.

引用

页码：235 / +

页数：22

共 153 条

[1] Systems Genetics of Metabolism: The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits [J].

Andreux, Penelope A. ;

Williams, Evan G. ;

Koutnikova, Hana ;

Houtkooper, Riekelt H. ;

Champy, Marie-France ;

Henry, Hugues ;

Schoonjans, Kristina ;

Williams, Robert W. ;

Auwerx, Johan .

CELL, 2012, 150 (06) :1287-1299

[2]

[Anonymous], 2017, SYSTEMS GENETICS

[3]

[Anonymous], 2008, NAT ED

[4] R/qtl: high-throughput multiple QTL mapping [J].

Arends, Danny ;

Prins, Pjotr ;

Jansen, Ritsert C. ;

Broman, Karl W. .

BIOINFORMATICS, 2010, 26 (23) :2990-2992

[5]

Ashbrook D.G., 2018, IBANGS M 20 ANN GEN, P4

[6] Offspring genes indirectly influence sibling and maternal behavioural strategies over resource share [J].

Ashbrook, David G. ;

Sharmin, Naorin ;

Hager, Reinmar .

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2017, 284 (1863)

[7] A cross-species genetic analysis identifies candidate genes for mouse anxiety and human bipolar disorder [J].

Ashbrook, David G. ;

Williams, Robert W. ;

Lu, Lu ;

Hager, Reinmar .

FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 2015, 9

[8] Transcript co-Variance With Nestin in two mouse genetic reference populations identifies Lef1 as a novel candidate regulator of neural precursor Cell proliferation in the adult hippocampus [J].

Ashbrook, David G. ;

Delprato, Anna ;

Grellmann, Claudia ;

Klein, Marieke ;

Wetzel, Richard ;

Overall, Rupert W. ;

Badea, Alexandra .

FRONTIERS IN NEUROSCIENCE, 2014, 8

[9] Joint genetic analysis of hippocampal size in mouse and human identifies a novel gene linked to neurodegenerative disease [J].

Ashbrook, David G. ;

Williams, Robert W. ;

Lu, Lu ;

Stein, Jason L. ;

Hibar, Derrek P. ;

Nichols, Thomas E. ;

Medland, Sarah E. ;

Thompson, Paul M. ;

Hager, Reinmar .

BMC GENOMICS, 2014, 15

[10] Empirical testing of hypotheses about the evolution of genomic imprinting in mammals [J].

Ashbrook, David G. ;

Hager, Reinmar .

FRONTIERS IN NEUROANATOMY, 2013, 7

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