Chemical methods for the synthesis and modification of neoclerodane diterpenes

被引：17

作者：

Lozama, Anthony ^{[1
,2
]}

Prisinzano, Thomas E. ^{[1
]}

机构：

[1] Univ Kansas, Dept Med Chem, Coll Pharm, Lawrence, KS 66046 USA

[2] Univ Iowa, Div Med & Nat Prod Chem, Coll Pharm, Iowa City, IA 52240 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 18期

关键词：

Diterpene; Neoclerodane; Salvinorin A; Salvia divinorum; KAPPA-OPIOID RECEPTOR; SALVINORIN-A ANALOGS; DEOXYXYLULOSE PHOSPHATE-PATHWAY; SALVIA-DIVINORUM; CLERODANE DITERPENOIDS; CALLICARPA-AMERICANA; ASYMMETRIC SYNTHESES; SALVINICIN-B; FURAN RING; AGONIST;

D O I：

10.1016/j.bmcl.2009.07.069

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Diterpenes are a structural class of molecules that are derived from four isoprene subunits and are widespread throughout nature. A number of neoclerodane diterpenes have been found to have biological activity but a limited number of chemical investigations have been conducted. Recently, the neoclerodane diterpene, salvinorin A (12) has been investigated due to its unique pharmacological profile. This review will discuss the chemical methods used to chemically modify and synthesize 12. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：5490 / 5495

页数：6

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