Dynamic regulation of histone lysine methylation by demethylases

被引：543
作者：
Shi, Yang [1 ]
Whetstine, Johnathan R. [1 ]
机构：
[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
来源：
MOLECULAR CELL | 2007年 / 25卷 / 01期
关键词：
D O I：
10.1016/j.molcel.2006.12.010
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent studies demonstrated that histone methylation is not static but is dynamically regulated by histone methyltransferases and the newly discovered histone demethylases. This review discusses the chemical mechanisms for the known and potentially new classes of demethylases, the roles of these demethylases in chromatin and transcription, and their potential biological functions and connections to human diseases.
引用
收藏
页码：1 / 14
页数：14
相关论文
共 112 条
  • [1] The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly
    Ahmad, K
    Henikoff, S
    [J]. MOLECULAR CELL, 2002, 9 (06) : 1191 - 1200
  • [2] ACETYLATION + METHYLATION OF HISTONES + THEIR POSSIBLE ROLE IN REGULATION OF RNA SYNTHESIS
    ALLFREY, VG
    FAULKNER, R
    MIRSKY, AE
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1964, 51 (05) : 786 - +
  • [3] ALLIS CD, 1980, CELL, V20, P55
  • [4] [Anonymous], 1989, Cladistics, DOI DOI 10.1111/J.1096-0031.1989.TB00562.X
  • [5] Aravind L., 2002, GENOME BIOL, V3, DOI DOI 10.1186/GB-2002-3-8-RESEARCH0039
  • [6] SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box
    Bai, C
    Sen, P
    Hofmann, K
    Ma, L
    Goebl, M
    Harper, JW
    Elledge, SJ
    [J]. CELL, 1996, 86 (02) : 263 - 274
  • [7] Evidence of domain swapping within the jumonji family of transcription factors
    Balciunas, D
    Ronne, H
    [J]. TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (06) : 274 - 276
  • [8] Histone methylation: Dynamic or static?
    Bannister, AJ
    Schneider, R
    Kouzarides, T
    [J]. CELL, 2002, 109 (07) : 801 - 806
  • [9] Bannister AJ, 2004, METHOD ENZYMOL, V376, P269
  • [10] Arginine methylation: An emerging regulator of protein function
    Bedford, MT
    Richard, S
    [J]. MOLECULAR CELL, 2005, 18 (03) : 263 - 272
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