Organozirconium-mediated solution- and solid-phase synthesis of 3-benzyl pyrrolidines and other potentially neuroactive amines

被引：11

作者：

Hunter, Rupert A. ^{[1
]}

Macfarlane, Donald P. S. ^{[1
]}

Whitby, Richard J. ^{[1
]}

机构：

[1] Univ Southampton, Sch Chem, Southampton SO17 1BJ, Hants, England

来源：

SYNLETT | 2006年 / 19期

关键词：

zirconium; neuroactive; pyrrolidine; solid-phase; library;

D O I：

10.1055/s-2006-951553

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient route to 3-benzylpyrrolidines using a zirconium-mediated cyclisation both in solution and on a solid support is reported. 3-Benzylidine-pyrrolidines, 3 -aryl-pyrrolidines and 4-arylpiperidines were also synthesised.

引用

页码：3314 / 3318

页数：5