Neural network involving medial orbitofrontal cortex and dorsal periaqueductal gray regulation in human alcohol abuse

被引：15

作者：

Jia, Tianye ^{[1
,2
,3
]}

Xie, Chao ^{[1
,2
]}

Banaschewski, Tobias ^{[4
]}

Barker, Gareth J. ^{[5
]}

Bokde, Arun L. W. ^{[6
,7
]}

Buechel, Christian ^{[8
]}

Quinlan, Erin Burke ^{[3
]}

Desrivieres, Sylvane ^{[3
]}

Flor, Herta ^{[9
,10
]}

Grigis, Antoine ^{[11
]}

Garavan, Hugh ^{[12
]}

Gowland, Penny ^{[13
]}

Heinz, Andreas ^{[14
,15
,16
,17
]}

Ittermann, Bernd ^{[18
,19
]}

Martinot, Jean-Luc ^{[20
]}

Martinot, Marie-Laure Paillere ^{[20
,21
]}

Nees, Frauke ^{[4
,9
,22
]}

Orfanos, Dimitri Papadopoulos ^{[11
]}

Poustka, Luise ^{[23
]}

Froehner, Juliane H. ^{[24
,25
]}

Smolka, Michael N. ^{[24
,25
]}

Walter, Henrik ^{[14
,15
,16
,17
]}

Whelan, Robert ^{[26
,27
]}

Schumann, Gunter ^{[1
,28
,29
,30
]}

Robbins, Trevor W. ^{[1
,31
,32
]}

Feng, Jianfeng ^{[1
,2
,33
,34
,35
,36
]}

机构：

[1] Fudan Univ, Inst Sci & Technol Brain Inspired Intelligence, Shanghai, Peoples R China

[2] Fudan Univ, Minist Educ, Key Lab Computat Neurosci & Brain Inspired Intell, Shanghai, Peoples R China

[3] Kings Coll London, Ctr Populat Neurosci & Precis Med PONS, SGDP Ctr, Inst Psychiat, London SE5 8AF, England

[4] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Child & Adolescent Psychiat & Psychotherapy, Sq J5, D-68159 Mannheim, Germany

[5] Kings Coll London, Inst Psychiat, Dept Neuroimaging, London, England

[6] Trinity Coll Dublin, Sch Med, Discipline Psychiat, Dublin, Ireland

[7] Trinity Coll Dublin, Trinity Coll, Inst Neurosci, Dublin, Ireland

[8] Univ Med Ctr Hamburg Eppendorf, Martinistr 52, Hamburg, Germany

[9] Heidelberg Univ, Med Fac Mannheim, Inst Cognit & Clin Neurosci, Cent Inst Mental Hlth, Sq J5, Mannheim, Germany

[10] Univ Mannheim, Sch Social Sci, Dept Psychol, D-68131 Mannheim, Germany

[11] Univ Paris Saclay, CEA, NeuroSpin, F-91191 Gif Sur Yvette, France

[12] Univ Vermont, Dept Psychiat, Burlington, VT 05405 USA

[13] Univ Nottingham, Sir Peter Mansfield Imaging Ctr, Sch Phys & Astron, Univ Pk, Nottingham, England

[14] Charite Univ Med Berlin, Dept Psychiat & Psychotherapy, Berlin, Germany

[15] Free Univ Berlin, Berlin, Germany

[16] Humboldt Univ, Berlin, Germany

[17] Berlin Inst Hlth, Berlin, Germany

[18] Phys Tech Bundesanstalt PTB, Braunschweig, Germany

[19] Phys Tech Bundesanstalt PTB, Berlin, Germany

[20] Univ Paris Saclay, Ctr Borelli, Inst Natl Sante & Rech Med, CNRS,INSERM U A10 Trajectoires Dev Psychiat,Ecole, Gif Sur Yvette, France

[21] Sorbonne Univ, Pitie Salpetriere Hosp, AP HP, Dept Child & Adolescent Psychiat, Paris, France

[22] Univ Kiel, Univ Med Ctr Schleswig Holstein, Inst Med Psychol & Med Sociol, Kiel, Germany

[23] Univ Med Ctr Gottingen, Dept Child & Adolescent Psychiat & Psychotherapy, Siebold Str 5, D-37075 Gottingen, Germany

[24] Tech Univ Dresden, Dept Psychiat, Dresden, Germany

[25] Tech Univ Dresden, Neuroimaging Ctr, Dresden, Germany

[26] Trinity Coll Dublin, Sch Psychol, Dublin, Ireland

[27] Trinity Coll Dublin, Global Brain Hlth Inst, Dublin, Ireland

[28] Charite Mental Hlth, Dept Psychiat & Psychotherapy, PONS Res Grp, Campus Charite Mitte, Berlin, Germany

[29] Univ Potsdam, Dept Sports & Hlth Sci, Potsdam, Germany

[30] Fudan Univ, PONS Ctr, Inst Sci & Technol Brain Inspired Intelligence IS, Shanghai, Peoples R China

[31] Univ Cambridge, Dept Psychol, Cambridge, England

[32] Univ Cambridge, Behav & Clin Neurosci Inst, Cambridge, England

[33] Fudan Univ, Sch Math Sci, Shanghai, Peoples R China

[34] Fudan Univ, Ctr Computat Syst Biol, Shanghai, Peoples R China

[35] Univ Warwick, Dept Comp Sci, Coventry, W Midlands, England

[36] Zhejiang Normal Univ, Fudan ISTBI ZJNU Algorithm Ctr Brain Inspired Int, Jinhua, Zhejiang, Peoples R China

来源：

SCIENCE ADVANCES | 2021年 / 7卷 / 06期

基金：

英国医学研究理事会; 欧盟地平线“2020”; 中国国家自然科学基金; 国家重点研发计划; 爱尔兰科学基金会;

关键词：

D O I：

10.1126/sciadv.abd4074

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Prompted by recent evidence of neural circuitry in rodent models, functional magnetic resonance imaging and functional connectivity analyses were conducted for a large adolescent population at two ages, together with alcohol abuse measures, to characterize a neural network that may underlie the onset of alcoholism. A network centered on the medial orbitofrontal cortex (mOFC), as well as including the dorsal periaqueductal gray (dPAG), central nucleus of the amygdala, and nucleus accumbens, was identified, consistent with the rodent models, with evidence of both inhibitory and excitatory coregulation by the mOFC over the dPAG. Furthermore, significant relationships were detected between raised baseline excitatory coregulation in this network and impulsivity measures, supporting a role for negative urgency in alcohol dependence.

引用

页数：10

共 3 条

[1] PROJECTIONS FROM MEDIAL PREFRONTAL CORTEX TO DORSAL PERIAQUEDUCTAL GRAY GATE COMPULSIVE ALCOHOL SEEKING
Noamany, H.
Siciliano, C. A.
Chen, X.
Leible, D.
Brown, A. R.
Chang, C.
Lee, J. J.
Wang, J.
Vernon, A. N.
Weele, C. M. Vander
Kimchi, E. Y.
Heiman, M.
Tye, K. M.
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2019, 43 : 151A - 151A
[2] Tonic pain alters functional connectivity of the descending pain modulatory network involving amygdala, periaqueductal gray, parabrachial nucleus and anterior cingulate cortex
Meeker, Timothy J.
Schmid, Anne-Christine
Keaser, Michael L.
Khan, Shariq A.
Gullapalli, Rao P.
Dorsey, Susan G.
Greenspan, Joel D.
Seminowicz, David A.
NEUROIMAGE, 2022, 256
[3] The representation of reward magnitude in the human ventral striatum and the medial orbitofrontal and ventromedial prefrontal cortex - An activation likelihood estimation meta-analysis with implications for a fundamental understanding of the human brain and substance abuse disorders
Kaps, L.
Gruber, O.
Falkai, F.
Diekhof, E. K.
PHARMACOPSYCHIATRY, 2011, 44 (06)

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