Synthesis of tetrahydro-β-carbolines and studies of the Pictet-Spengler reaction

被引：27

作者：

Ducrot, P ^{[1
]}

Rabhi, C ^{[1
]}

Thal, C ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

TETRAHEDRON | 2000年 / 56卷 / 17期

关键词：

Pictet-Spengler reaction; alpha-aminoaldehydes; tryptamine;

D O I：

10.1016/S0040-4020(00)00165-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Tetrahydro-beta-carbolines have been prepared in a diastereomerically pure form by a short, efficient synthetic sequence consisting of reaction of cl-aminoaldehydes with tryptamine. A study was made of the major factors affecting the stereoselectivity of the Pictet-Spengler reaction. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：2683 / 2692

页数：10

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