Synthesis of tetrahydro-β-carbolines and studies of the Pictet-Spengler reaction

被引：27
|
作者：
Ducrot, P [1 ]
Rabhi, C [1 ]
Thal, C [1 ]
机构：
[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France
来源：
TETRAHEDRON | 2000年 / 56卷 / 17期
关键词：
Pictet-Spengler reaction; alpha-aminoaldehydes; tryptamine;
D O I：
10.1016/S0040-4020(00)00165-4
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Tetrahydro-beta-carbolines have been prepared in a diastereomerically pure form by a short, efficient synthetic sequence consisting of reaction of cl-aminoaldehydes with tryptamine. A study was made of the major factors affecting the stereoselectivity of the Pictet-Spengler reaction. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：2683 / 2692
页数：10
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