Haplotypes of IL6 and IL10 and susceptibility to human T lymphotropic virus type I infection among children

被引：3
作者：
Brown, Elizabeth E.
Brown, Brandon J.
Yeager, Meredith
Welch, Robert
Cranston, Beverly
Hanchard, Barrie
Hisada, Michie
机构：
[1] NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Rockville, MD 20852 USA
[2] NCI, Sci Applicat Int Corp Frederick Inc, Core Genotyping Facil, Ctr Adv Technol, Gaithersburg, MD USA
[3] Univ Calif Los Angeles, Dept Epidemiol, Los Angeles, CA USA
[4] Univ W Indies, Dept Pathol, Kingston 7, Jamaica
来源：
JOURNAL OF INFECTIOUS DISEASES | 2006年 / 194卷 / 11期
关键词：
D O I：
10.1086/508783
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
To characterize a host polygenic profile associated with susceptibility to human T lymphotropic virus type I (HTLV-I) infection, we examined common variants in 11 immunerelated genes among Jamaican children born to HTLV-I seropositive mothers. Compared with HTLV-I seronegatives, haplotypes of IL6 (-660G/-635C/-236G) and IL10 (-6653C/-1116G) were significantly associated with HTLV-I infection in children independent of maternal provirus load and duration of breast-feeding (odds ratio [OR], 4.5 [95% confidence interval {CI}, 1.2-17.6], and OR, 3.5 [95% CI, 1.4-9.0], respectively). Our findings are the first, to our knowledge, to suggest that host variation in both proinflammatory and anti-inflammatory genes could influence susceptibility to HTLV-I infection.
引用
收藏
页码：1565 / 1569
页数：5
相关论文
共 15 条
  • [1] Host immunogenetics and control of human herpesvirus-8 infection
    Brown, EE
    Fallin, MD
    Goedert, JJ
    Hutchinson, A
    Vitale, F
    Lauria, C
    Giuliani, M
    Marshall, V
    Mbisa, G
    Serraino, D
    Messina, A
    Durum, S
    Whitby, D
    Chanock, SJ
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2006, 193 (08) : 1054 - 1062
  • [2] The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis
    Fishman, D
    Faulds, G
    Jeffery, R
    Mohamed-Ali, V
    Yudkin, JS
    Humphries, S
    Woo, P
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1998, 102 (07) : 1369 - 1376
  • [3] Virus markers associated with vertical transmission of human T lymphotropic virus type 1 in Jamaica
    Hisada, M
    Maloney, EM
    Sawada, T
    Miley, WJ
    Palmer, P
    Hanchard, B
    Goedert, JJ
    Manns, A
    [J]. CLINICAL INFECTIOUS DISEASES, 2002, 34 (12) : 1551 - 1557
  • [4] IL6 AND THE T-CELL RESPONSE
    HOUSSIAU, F
    VANSNICK, J
    [J]. RESEARCH IN IMMUNOLOGY, 1992, 143 (07): : 740 - 743
  • [5] HOUSSIAU FA, 1989, J IMMUNOL, V143, P2520
  • [6] *IARC WHO, 1996, IARC MON EV CARC RIS, V67
  • [7] KAPLAN JE, 1990, J ACQ IMMUN DEF SYND, V3, P1096
  • [8] Human T-cell leukemia virus type I and adult T-cell leukemia
    Matsuoka, M
    [J]. ONCOGENE, 2003, 22 (33) : 5131 - 5140
  • [9] Mori N, 1996, BLOOD, V88, P1035
  • [10] Association between interleukin-6 gene polymorphism and human T-cell leukemia virus type I associated myelopathy
    Nishimura, M
    Matsuoka, M
    Maeda, M
    Mizuta, I
    Mita, S
    Uchino, M
    Matsui, M
    Kuroda, Y
    Kawakami, H
    Kaji, R
    Adachi, A
    Uchiyama, T
    [J]. HUMAN IMMUNOLOGY, 2002, 63 (08) : 696 - 700
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