Complete coding sequence of hepatitis C virus genotype 6a

被引：44

作者：

Adams, NJ

Chamberlain, RW

Taylor, LA

Davidson, F

Lin, CK

Elliott, RM

Simmonds, P

机构：

[1] UNIV EDINBURGH,DEPT MED MICROBIOL,EDINBURGH EH8 9AG,MIDLOTHIAN,SCOTLAND

[2] UNIV GLASGOW,INST VIROL,GLASGOW G11 5JR,LANARK,SCOTLAND

[3] HONG KONG RED CROSS BLOOD TRANSFUS SERV,KOWLOON,HONG KONG

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 234卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1006/bbrc.1997.6627

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Hepatitis C virus (HCV) genotype 6a is found in a restricted part of South East Asia, including Hong Kong, Macau and Vietnam. We determined the full length coding sequence of a type 6a isolate (EUHK2) obtained from a Hong Kong blood donor. The sequence of EUHK2 contained a single open reading frame coding for a polyprotein of 3018 amino acids, within the range of 3008 to 3037 for other HCV genotypes. The full length sequence of EUHK2 showed 30.3%-32.9% nucleotide (24.3%-29.4% amino acid) sequence divergence from genotypes 1-4, but only 27.7% (20.7% amino acid) divergence from JK046 (''type 11a''). These similarity values were intermediate between those of other HCV genotypes (minimum 28.4%) and between subtypes (maximum 25%). The close evolutionary relationship of EUHK2 with JK046 was further indicated by their grouping together by phylogenetic analysis. (C) 1997 Academic Press.

引用

收藏

页码：393 / 396

页数：4

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