Micropulse laser in patients with refractory and treatment-naive center-involved diabetic macular edema: short terms visual and anatomic outcomes

被引：10

作者：

Valera-Cornejo, Diego Alejandro ^{[1
]}

Garcia-Roa, Marlon ^{[1
]}

Quiroz-Mendoza, Jaime ^{[1
]}

Arias-Gomez, Alejandro ^{[1
]}

Ramirez-Neria, Paulina ^{[1
]}

Villalpando-Gomez, Yolanda ^{[1
]}

Romero-Morales, Veronica ^{[1
]}

Garcia-Franco, Renata ^{[1
]}

机构：

[1] Inst Mexicano Oftalmol IAP, Retina Dept, Santiago De Queretaro, Qro, Mexico

来源：

THERAPEUTIC ADVANCES IN OPHTHALMOLOGY | 2021年 / 13卷

关键词：

best-corrected visual acuity; central macular thickness; diabetic macular edema; 577nm; macular capillary leakage; macular volume; photocoagulation; Subthreshold Micropulse Laser; DIODE-LASER; RETINAL LASER; PHOTOCOAGULATION; THERAPY; EFFICACY; RANIBIZUMAB; RETINOPATHY; SAFETY; DEGENERATION; AFLIBERCEPT;

D O I：

10.1177/2515841420979112

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: The purpose of the study is to describe visual and anatomic outcomes of 5774nm micropulse laser photocoagulation in eyes with either treatment-naive or refractory diabetic macular edema (DME) at 3 months. Methods: This was a prospective case series that recruited 23 consecutive patients (33 eyes) with center-involved DME that was either treatment-naive or had not responded to prior treatment. Micropulse therapy was performed with the Easy Ret 577 (Quantel Medical, Cournon d'Auvergne, France) diode laser in a high-density manner in eyes with treatment-naive or refractory DME. The primary outcome was the change of best-corrected visual acuity (BCVA; logMAR) at 1 and 3 months. Secondary outcomes were changes in the central macular thickness (CMT), thickness area, macular volume, and macular capillary leakage at 1 and 3 months. Results: There were no significant changes in BCVA at 3 months, with mean +/- standard deviation (SD) of -0.08 +/- 0.01 (p = 0.228) and + 0.01 +/- 0.01 (p = 0.969) for treatment-naive and refractory groups, respectively. The change in CMT at 3 months was statistically but not clinically significant in the treatment-naive group only (mean +/- SD; -30 +/- 130 mu m; p = 0.011). The macular volume and area thickness change were not statistically significant (p = 0.173 and p = 0.148 for macular volume and area thickness, respectively) in the treatment-naive group. There was no difference concerning the leakage area in both groups. No adverse events were reported. Conclusion: We concluded that micropulse 577nm laser therapy maintained the visual acuity and macular thickness at 3 months in both treatment-naive and refractory DME.

引用

页数：11